Methods for the Quantitative Determination of Multiple, Specific Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Isomers in Human Adipose Tissue in the Parts-per-Trillion Range. An Interlaboratory Study

P. W. Albro, W. B. Crummett, L. L. Lamparski, T. J. Nestrick, T. L. Peters, A. E. Dupuy, R. L. Harless, D. D. McDaniel, M. L. Gross, J. L. Meehan, N. C.A. Weerasinghe, M. Hanson, M. Nygren, C. Rappe, F. D. Hileman, J. M. Wendling, D. Hilker, P. O'Keefe, C. Jason, J. L. JohnsonL. M. Smith, D. L. Stalling, B. P.Y. Lau, J. J. Ryan

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Abstract

Eight different approaches were applied In eight analytical laboratories to the quantitative determination of four chlorinated dibenzo-p-dioxins (2,3,7,8-Cl4; 1,2,3,7,8-Cl5; 1,2,3,4,7,8-Cl8; and 1,2,3,4,6,7,8,9-Cl8) and three chlorinated dibenzofurans (2,3,7,8-Cl4; 2,3,4,7,8-Cl5; and 1,2,3,7,8,9-Cl6) in spiked samples of an extract of human adipose tissue. One aspect of this blind study was the inclusion of potential interferences (polychlorinated biphenyls, PCBs; chlorinated diphenyl ethers; chlorinated methoxybiphenyls; DDE; other Cl4, Cl5, and Cl6 chlorinated dibenzofurans; and 1,2,3,4- tetra-chlorodibenzo-p-dioxin). Levels of fortification (unknown to the participating laboratories) were In the 5–50 pptr (parts-per-trillion) range except for octachlorodlbenzo-p-dioxin (up to 500 pptr). Results Indicated that most of the tested procedures gave a high degree of qualitative reliability. Several aspects of quantification were Identified in which improvement is possible. No one method was found to be clearly superior to all others. A number of future research needs were identified to help ensure and improve quantitative reliability in multicomponent analysis at the parts-per-trillion level.

Original languageEnglish
Pages (from-to)2717-2725
Number of pages9
JournalAnalytical Chemistry
Volume57
Issue number13
DOIs
StatePublished - Nov 1985

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