Method for quantitative broadband diffuse optical spectroscopy of tumor-like inclusions

Sandhya Vasudevan, Farnoush Forghani, Chris Campbell, Savannah Bedford, Thomas D. O'Sullivan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A hybrid reflectance-based diffuse optical imaging (DOI) technique combining discrete wavelength frequency-domain (FD) near-infrared spectroscopy (NIRS) with broadband continuous wave NIRS measurements was developed to quantify the broadband optical properties of deep tumor-like inclusions. This method was developed to more accurately measure the broadband optical properties of human tumors using a compact handheld imaging probe and without requiring a priori spectral constraints. We simulated the reconstruction of absorption and scattering spectra (650-1000 nm) of human breast tumors in a homogeneous background at depths of 0 to 10 mm. The hybrid DOI technique demonstrated enhanced performance in reconstruction of optical absorption with a mean accuracy over all 71 wavelengths of 8.39% versus 32.26% for a 10 mm deep tumor with the topographic DOI method. The new hybrid technique was also tested and validated on two heterogeneous tissue-simulating phantoms with inclusion depths of 2, 7, and 9 mm. The mean optical absorption accuracy over all wavelengths was similarly improved up to 5x for the hybrid DOI method versus topographic DOI for the deepest inclusions.

Original languageEnglish
Article number1419
JournalApplied Sciences (Switzerland)
Volume10
Issue number4
DOIs
StatePublished - Feb 1 2020

Keywords

  • Broadband imaging
  • Diffuse optical imaging
  • Diffuse optical spectroscopy
  • Hybrid frequency-domain (FD) continuous-wave (CW) method
  • Hyperspectral diffuse optical imaging
  • Multispectral imaging

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