@article{886706beef84446d89b6fae0f45af4db,
title = "Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells",
abstract = "Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.",
keywords = "CNS regeneration, adult stem cell, aging, dietary restriction, metformin, oligodendrocyte progenitor cell, rejuvenation, remyelination",
author = "Bj{\"o}rn Neumann and Roey Baror and Chao Zhao and Michael Segel and Sabine Dietmann and Rawji, \{Khalil S.\} and Sarah Foerster and McClain, \{Crystal R.\} and Kevin Chalut and \{van Wijngaarden\}, Peter and Franklin, \{Robin J.M.\}",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = oct,
day = "3",
doi = "10.1016/j.stem.2019.08.015",
language = "English",
volume = "25",
pages = "473--485.e8",
journal = "Cell Stem Cell",
issn = "1934-5909",
number = "4",
}