@article{886706beef84446d89b6fae0f45af4db,
title = "Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells",
abstract = "Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.",
keywords = "CNS regeneration, adult stem cell, aging, dietary restriction, metformin, oligodendrocyte progenitor cell, rejuvenation, remyelination",
author = "Bj{\"o}rn Neumann and Roey Baror and Chao Zhao and Michael Segel and Sabine Dietmann and Rawji, {Khalil S.} and Sarah Foerster and McClain, {Crystal R.} and Kevin Chalut and {van Wijngaarden}, Peter and Franklin, {Robin J.M.}",
note = "Funding Information: This work was supported by funding from the UK Multiple Sclerosis Society, MedImmune, The Adelson Medical Research Foundation, and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. P.v.W. was supported by the National Health and Medical Research Council of Australia (ECF #628928). We thank Dr. Daniel Morrison for assistance with electron microscopy, the NIHR Cambridge BRC Cell Phenotyping Hub for all flow cytometry work, and the staff at the Cambridge Advanced Imaging Centre. Conceptualization, B.N. P.v.W. and R.J.M.F.; Methodology, B.N. R.B. and C.M.; Investigation, B.N. R.B. C.Z. M.S. K.S.R. and S.F.; Formal Analysis, B.N. R.B. C.Z. S.D. K.S.R. P.v.W. and R.J.F.M.; Writing, B.N. K.C. P.v.W. and R.J.M.F.; Funding Acquisition, R.J.M.F.; Supervision, P.v.W. and R.J.M.F. The authors declare that there are patent applications pending related to this work. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = oct,
day = "3",
doi = "10.1016/j.stem.2019.08.015",
language = "English",
volume = "25",
pages = "473--485.e8",
journal = "Cell Stem Cell",
issn = "1934-5909",
number = "4",
}