Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

Björn Neumann; Roey Baror; Chao Zhao; Michael Segel; Sabine Dietmann; Khalil S. Rawji; Sarah Foerster; Crystal R. McClain; Kevin Chalut; Peter van Wijngaarden; Robin J.M. Franklin

doi:10.1016/j.stem.2019.08.015

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

Björn Neumann, Roey Baror, Chao Zhao, Michael Segel, Sabine Dietmann, Khalil S. Rawji, Sarah Foerster, Crystal R. McClain, Kevin Chalut, Peter van Wijngaarden, Robin J.M. Franklin

Research output: Contribution to journal › Article › peer-review

282 Scopus citations

Abstract

Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.

Original language	English
Pages (from-to)	473-485.e8
Journal	Cell Stem Cell
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2019.08.015
State	Published - Oct 3 2019

Keywords

CNS regeneration
adult stem cell
aging
dietary restriction
metformin
oligodendrocyte progenitor cell
rejuvenation
remyelination

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10.1016/j.stem.2019.08.015

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title = "Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells",

abstract = "Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.",

keywords = "CNS regeneration, adult stem cell, aging, dietary restriction, metformin, oligodendrocyte progenitor cell, rejuvenation, remyelination",

author = "Bj{\"o}rn Neumann and Roey Baror and Chao Zhao and Michael Segel and Sabine Dietmann and Rawji, {Khalil S.} and Sarah Foerster and McClain, {Crystal R.} and Kevin Chalut and {van Wijngaarden}, Peter and Franklin, {Robin J.M.}",

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AU - Neumann, Björn

AU - Baror, Roey

AU - Zhao, Chao

AU - Segel, Michael

AU - Dietmann, Sabine

AU - Rawji, Khalil S.

AU - Foerster, Sarah

AU - McClain, Crystal R.

AU - Chalut, Kevin

AU - van Wijngaarden, Peter

AU - Franklin, Robin J.M.

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.

AB - Neumann et al. demonstrate that aging renders adult oligodendrocyte progenitor cells unresponsive to pro-differentiation factors, which can be reversed both in vitro and in vivo by calorie restriction (CR) and the CR mimetic metformin.

KW - CNS regeneration

KW - adult stem cell

KW - aging

KW - dietary restriction

KW - metformin

KW - oligodendrocyte progenitor cell

KW - rejuvenation

KW - remyelination

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JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

Abstract

Keywords

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