Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

Marc R. Reboll; Stefanie Klede; Manuel H. Taft; Chen Leng Cai; Loren J. Field; Kory J. Lavine; Andrew L. Koenig; Jenni Fleischauer; Johann Meyer; Axel Schambach; Hans W. Niessen; Maike Kosanke; Joop van den Heuvel; Andreas Pich; Johann Bauersachs; Xuekun Wu; Linqun Zheng; Yong Wang; Mortimer Korf-Klingebiel; Felix Polten; Kai C. Wollert

doi:10.1126/science.abn3027

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

Marc R. Reboll, Stefanie Klede, Manuel H. Taft, Chen Leng Cai, Loren J. Field, Kory J. Lavine, Andrew L. Koenig, Jenni Fleischauer, Johann Meyer, Axel Schambach, Hans W. Niessen, Maike Kosanke, Joop van den Heuvel, Andreas Pich, Johann Bauersachs, Xuekun Wu, Linqun Zheng, Yong Wang, Mortimer Korf-Klingebiel, Felix PoltenKai C. Wollert

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair.

Original language	English
Pages (from-to)	1343-1347
Number of pages	5
Journal	Science
Volume	376
Issue number	6599
DOIs	https://doi.org/10.1126/science.abn3027
State	Published - Jun 17 2022

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Reboll, M. R., Klede, S., Taft, M. H., Cai, C. L., Field, L. J., Lavine, K. J., Koenig, A. L., Fleischauer, J., Meyer, J., Schambach, A., Niessen, H. W., Kosanke, M., van den Heuvel, J., Pich, A., Bauersachs, J., Wu, X., Zheng, L., Wang, Y., Korf-Klingebiel, M., ... Wollert, K. C. (2022). Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science, 376(6599), 1343-1347. https://doi.org/10.1126/science.abn3027

@article{d54b6e9308c34cadb6804a8b1e4326ff,

title = "Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase",

abstract = "Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair.",

author = "Reboll, {Marc R.} and Stefanie Klede and Taft, {Manuel H.} and Cai, {Chen Leng} and Field, {Loren J.} and Lavine, {Kory J.} and Koenig, {Andrew L.} and Jenni Fleischauer and Johann Meyer and Axel Schambach and Niessen, {Hans W.} and Maike Kosanke and {van den Heuvel}, Joop and Andreas Pich and Johann Bauersachs and Xuekun Wu and Linqun Zheng and Yong Wang and Mortimer Korf-Klingebiel and Felix Polten and Wollert, {Kai C.}",

year = "2022",

month = jun,

day = "17",

doi = "10.1126/science.abn3027",

language = "English",

volume = "376",

pages = "1343--1347",

journal = "Science",

issn = "0036-8075",

number = "6599",

}

Reboll, MR, Klede, S, Taft, MH, Cai, CL, Field, LJ, Lavine, KJ , Koenig, AL, Fleischauer, J, Meyer, J, Schambach, A, Niessen, HW, Kosanke, M, van den Heuvel, J, Pich, A, Bauersachs, J, Wu, X, Zheng, L, Wang, Y, Korf-Klingebiel, M, Polten, F & Wollert, KC 2022, 'Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase', Science, vol. 376, no. 6599, pp. 1343-1347. https://doi.org/10.1126/science.abn3027

TY - JOUR

T1 - Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

AU - Reboll, Marc R.

AU - Klede, Stefanie

AU - Taft, Manuel H.

AU - Cai, Chen Leng

AU - Field, Loren J.

AU - Lavine, Kory J.

AU - Koenig, Andrew L.

AU - Fleischauer, Jenni

AU - Meyer, Johann

AU - Schambach, Axel

AU - Niessen, Hans W.

AU - Kosanke, Maike

AU - van den Heuvel, Joop

AU - Pich, Andreas

AU - Bauersachs, Johann

AU - Wu, Xuekun

AU - Zheng, Linqun

AU - Wang, Yong

AU - Korf-Klingebiel, Mortimer

AU - Polten, Felix

AU - Wollert, Kai C.

PY - 2022/6/17

Y1 - 2022/6/17

N2 - Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair.

AB - Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair.

UR - http://www.scopus.com/inward/record.url?scp=85132322824&partnerID=8YFLogxK

U2 - 10.1126/science.abn3027

DO - 10.1126/science.abn3027

M3 - Article

C2 - 35709278

AN - SCOPUS:85132322824

SN - 0036-8075

VL - 376

SP - 1343

EP - 1347

JO - Science

JF - Science

IS - 6599

ER -

Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase

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