Metastasis suppressor genes

Jinchun Yan, Qin Yang, Qihong Huang

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Metastasis is a major cause of cancer mortality. Metastasis is a complex process that requires the regulation of both metastasis-promoting and metastasis suppressor genes. The discovery of metastasis suppressor genes contributes significantly to our understanding of metastasis mechanisms and provides prognostic markers and therapeutic targets in clinical cancer management. In this review, we summarize the methods that have been used to identify metastasis suppressors and the potential clinical impact of these genes.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalHistology and Histopathology
Volume28
Issue number3
StatePublished - Mar 2013

Keywords

  • Functional genomics
  • Metastasis
  • Metastasis suppressor
  • Next generation sequencing
  • RNA interference

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