TY - JOUR
T1 - Metaplastic Squamous Epithelial Downgrowth After Clear Corneal Cataract Surgery
AU - Stone, Donald U.
AU - Char, Devron H.
AU - Crawford, J. Brooks
AU - Margolis, Todd P.
AU - Van Gelder, Russell N.
AU - Strauss, Erich C.
PY - 2006/10
Y1 - 2006/10
N2 - Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.
AB - Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.
UR - http://www.scopus.com/inward/record.url?scp=33748969190&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2006.04.044
DO - 10.1016/j.ajo.2006.04.044
M3 - Article
C2 - 17011874
AN - SCOPUS:33748969190
SN - 0002-9394
VL - 142
SP - 695
EP - 697
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -