Metabotropic glutamate receptor 5 in conditioned taste aversion learning

A. Simonyi, P. Serfozo, K. E. Parker, A. K. Ramsey, T. R. Schachtman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


In conditioned taste aversion (CTA), animals learn to avoid a flavored solution (conditioned stimulus, CS) previously paired with internal malaise (unconditioned stimulus, US). Metabotropic glutamate receptor 5 (mGlu5) has been implicated in learning and memory processes and is necessary for CTA. In the present study, local microinjections of a mGlu5-selective antagonist, 3-[2-methyl-1,3-thiazol-4yl)ethynyl]pyridine (MTEP, 0, 1 or 5 μg) into the insular cortex and basolateral amygdala were used in male, Sprague-Dawley rats to examine the role of mGlu5 receptors in the encoding of taste memory. MTEP was infused 20 min before saccharin intake during CTA conditioning. MTEP injection into the basolateral amygdala resulted in robust CTA, similar to the vehicle-treated animals but slowed extinction; that is, MTEP enhanced CTA. MTEP injection into the insular cortex resulted in an increased saccharin intake on the conditioning trial, which potentially influenced the performance on the test trials; MTEP had no effect on CTA learning when controlled access to saccharin was used on the conditioning trial. These results indicate that mGlu5 receptors are involved in taste memories in a region-specific manner.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalNeurobiology of Learning and Memory
Issue number3
StatePublished - Oct 2009


  • Acquisition
  • Amygdala
  • Conditioned taste aversion
  • Insular cortex
  • Metabotropic glutamate receptor 5


Dive into the research topics of 'Metabotropic glutamate receptor 5 in conditioned taste aversion learning'. Together they form a unique fingerprint.

Cite this