TY - JOUR
T1 - Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin
AU - Patti, Gary J.
AU - Yanes, Oscar
AU - Shriver, Leah P.
AU - Courade, Jean Phillipe
AU - Tautenhahn, Ralf
AU - Manchester, Marianne
AU - Siuzdak, Gary
N1 - Funding Information:
This work was supported by the US National Institutes of Health (NIH) R24 EY017540-04 (G.S.), P30 MH062261 (M.M., G.S.) and P01 DA026146-02 (G.S.) in addition to RR025774 (M.M.); NIH–National Institute of Aging L30 AG0 038036 (G.J.P.); and NIH–National Institute of Neurological Disorders and Stroke F32NS068015 and T32 NSO41219 (L.P.S.). We also acknowledge financial support from the US Department of Energy FG02-07ER64325 and DE-AC0205CH11231).
PY - 2012/3
Y1 - 2012/3
N2 - Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo. These results demonstrate the utility of metabolomics to implicate unexplored biochemical pathways in disease.
AB - Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo. These results demonstrate the utility of metabolomics to implicate unexplored biochemical pathways in disease.
UR - http://www.scopus.com/inward/record.url?scp=84857195689&partnerID=8YFLogxK
U2 - 10.1038/nchembio.767
DO - 10.1038/nchembio.767
M3 - Article
AN - SCOPUS:84857195689
SN - 1552-4450
VL - 8
SP - 232
EP - 234
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 3
ER -