Metabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Katarzyna Polonis, Renata Wawrzyniak, Emilia Daghir-Wojtkowiak, Anna Szyndler, Marzena Chrostowska, Olle Melander, Michał Hoffmann, Marta Kordalewska, Joanna Raczak-Gutknecht, Ewa Bartosińska, Roman Kaliszan, Krzysztof Narkiewicz, Michał J. Markuszewski

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolomic approach was used to identify plasma metabolites in an age-, BMI-, and sex-matched groups of EVA (n = 79) and non-EVA (n = 73) individuals with hypertension. After raw data processing and filtration, 497 putative compounds were characterized, out of which 4 were identified as lysophosphaditylcholines (LPCs) [LPC (18:2), LPC (16:0), LPC (18:0), and LPC (18:1)]. A main finding of this study shows that identified LPCs were independently associated with EVA status. Although LPCs have been shown previously to be positively associated with inflammation and atherosclerosis, we observed that hypertensive individuals characterized by 4 down-regulated LPCs had 3.8 times higher risk of EVA compared to those with higher LPC levels (OR = 3.8, 95% CI 1.7–8.5, P < 0.001). Our results provide new insights into a metabolomic phenotype of vascular aging and warrants further investigation of negative association of LPCs with EVA status. This study suggests that LPCs are potential candidates to be considered for further evaluation and validation as predictors of EVA in patients with hypertension.

Original languageEnglish
Article number12
JournalFrontiers in Molecular Biosciences
StatePublished - Feb 7 2020


  • arterial stiffness
  • early vascular aging
  • metabolomics
  • phospholipid metabolism
  • pulse wave velocity


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