Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product

F. Nicholas Franano, W. Barry Edwards, Michael J. Welch, James R. Duncan

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The hepatic and renal retention of indium-111 (111In) from 111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of 111In-DTPA-labeled glycoproteins targeted to cell surface receptors in vitro and in vivo. We found that 111In-DTPA-glycoproteins were degraded to 111In-DTPA-ε{lunate}-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for 111In retention at target and non-target sites.

Original languageEnglish
Pages (from-to)1023-1034
Number of pages12
JournalNuclear Medicine and Biology
Volume21
Issue number8
DOIs
StatePublished - Nov 1994

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