Metabolism of beta-methyl[1-11C]heptadecanoic acid in canine myocardium

Dana R. Abendschein, Keith A.A. Fox, H. Dieter Ambos, Burton E. Sobel, Steven R. Bergmann

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12 Scopus citations

Abstract

To assess the contributions of metabolism to CO2 and back-diffusion of nonmetabolized tracer to total clearance of beta-methyl[1-11C]heptadecanoic acid ([1-11C]BMHDA) from myocardium and its distribution into lipid pools, 10-15 mCi of [1-11C]BMHDA were rapidly infused into the circumflex coronary artery of seven open-chest dogs. Externally detected clearance of myocardial 11C-activity was protracted (t 1 2 = 41 ± 18 min) with over 50% of extracted tracer retained in tissue after 20 min. Efflux of extracted [1-11C]BMHDA between 5 and 20 min was comprised of both 11CO2 (16.5 ± 15.2%) and nonmetabolized [11C]BMHDA (24.6 ± 11.5%). At 20 min, 11C-activity in lipid was distributed primarily between triglyceride (47 ± 16% of total) and phospholipid (39 ± 17%) pools. Partial oxidation to 11CO2 and partitioning into more than one lipid pool are likely to hinder evaluation of fatty acid metabolism based on residue detection of [1-11C]BMHDA with tomography.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume14
Issue number6
DOIs
StatePublished - 1987

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