TY - JOUR
T1 - Metabolism of beta-methyl[1-11C]heptadecanoic acid in canine myocardium
AU - Abendschein, Dana R.
AU - Fox, Keith A.A.
AU - Ambos, H. Dieter
AU - Sobel, Burton E.
AU - Bergmann, Steven R.
N1 - Funding Information:
This work was supported in part by National Institute of Health grant HL 17646, SCOR in Ischemic Heart Disease. Address correspondence to: Dana R. Abcndschein, Ph.D., Cardiovascular Division, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, U.S.A. [Tel: (314) 362-89201.
PY - 1987
Y1 - 1987
N2 - To assess the contributions of metabolism to CO2 and back-diffusion of nonmetabolized tracer to total clearance of beta-methyl[1-11C]heptadecanoic acid ([1-11C]BMHDA) from myocardium and its distribution into lipid pools, 10-15 mCi of [1-11C]BMHDA were rapidly infused into the circumflex coronary artery of seven open-chest dogs. Externally detected clearance of myocardial 11C-activity was protracted (t 1 2 = 41 ± 18 min) with over 50% of extracted tracer retained in tissue after 20 min. Efflux of extracted [1-11C]BMHDA between 5 and 20 min was comprised of both 11CO2 (16.5 ± 15.2%) and nonmetabolized [11C]BMHDA (24.6 ± 11.5%). At 20 min, 11C-activity in lipid was distributed primarily between triglyceride (47 ± 16% of total) and phospholipid (39 ± 17%) pools. Partial oxidation to 11CO2 and partitioning into more than one lipid pool are likely to hinder evaluation of fatty acid metabolism based on residue detection of [1-11C]BMHDA with tomography.
AB - To assess the contributions of metabolism to CO2 and back-diffusion of nonmetabolized tracer to total clearance of beta-methyl[1-11C]heptadecanoic acid ([1-11C]BMHDA) from myocardium and its distribution into lipid pools, 10-15 mCi of [1-11C]BMHDA were rapidly infused into the circumflex coronary artery of seven open-chest dogs. Externally detected clearance of myocardial 11C-activity was protracted (t 1 2 = 41 ± 18 min) with over 50% of extracted tracer retained in tissue after 20 min. Efflux of extracted [1-11C]BMHDA between 5 and 20 min was comprised of both 11CO2 (16.5 ± 15.2%) and nonmetabolized [11C]BMHDA (24.6 ± 11.5%). At 20 min, 11C-activity in lipid was distributed primarily between triglyceride (47 ± 16% of total) and phospholipid (39 ± 17%) pools. Partial oxidation to 11CO2 and partitioning into more than one lipid pool are likely to hinder evaluation of fatty acid metabolism based on residue detection of [1-11C]BMHDA with tomography.
UR - http://www.scopus.com/inward/record.url?scp=45949131128&partnerID=8YFLogxK
U2 - 10.1016/0883-2897(87)90029-8
DO - 10.1016/0883-2897(87)90029-8
M3 - Article
C2 - 3429239
AN - SCOPUS:45949131128
VL - 14
SP - 579
EP - 585
JO - International Journal of Radiation Applications and Instrumentation.
JF - International Journal of Radiation Applications and Instrumentation.
SN - 0883-2897
IS - 6
ER -