TY - JOUR
T1 - Metabolic syndrome is associated with abnormal left ventricular diastolic function independent of left ventricular mass
AU - Fuentes, Lisa De Las
AU - Brown, Angela L.
AU - Mathews, Santhosh J.
AU - Waggoner, Alan D.
AU - Soto, Pablo F.
AU - Gropler, Robert J.
AU - Dávila-Román, Víctor G.
PY - 2007/3
Y1 - 2007/3
N2 - Aim: To characterize the extent to which metabolic syndrome criteria predict left ventricular (LV) structure and function. Methods and results: Metabolic syndrome criteria were assessed in 607 adults with normal LV function. The cohort was grouped according to the number of criteria satisfied: (1) Absent (0 criteria, n = 110); (2) Pre-Metabolic Syndrome (1-2 criteria, n = 311); and (3) Metabolic Syndrome (≥3 criteria, n = 186). Echocardiography was used to assess LV structure (LV mass) and systolic (LVEF, Vs) and diastolic function, by pulse-wave Doppler (E/A ratio) and tissue Doppler imaging (Ve). LV volumes and LVEF were similar between groups. However, LV mass increased significantly and progressively (LVM/Ht2.7, in g/m2.7: 34.9 ± 6.7, 41.0 ± 9.5, 46.3 ± 11.0, P < 0.001); LV relaxation decreased progressively (Veglobal′, in cm/s: 13.5 ± 2.8, 12.1 ± 3.0, 10.5 ± 2.2, P < 0.001) from Absent to Pre-Metabolic Syndrome to Metabolic Syndrome groups, respectively. Multiple variable analyses showed that diastolic blood pressure, waist circumference, and triglyceride levels were independent predictors of Ve after adjustment for LV mass. Conclusion: Patients with metabolic syndrome have LV diastolic dysfunction independent of LV mass. These functional abnormalities may partially explain the increased cardiovascular morbidity and mortality associated with metabolic syndrome.
AB - Aim: To characterize the extent to which metabolic syndrome criteria predict left ventricular (LV) structure and function. Methods and results: Metabolic syndrome criteria were assessed in 607 adults with normal LV function. The cohort was grouped according to the number of criteria satisfied: (1) Absent (0 criteria, n = 110); (2) Pre-Metabolic Syndrome (1-2 criteria, n = 311); and (3) Metabolic Syndrome (≥3 criteria, n = 186). Echocardiography was used to assess LV structure (LV mass) and systolic (LVEF, Vs) and diastolic function, by pulse-wave Doppler (E/A ratio) and tissue Doppler imaging (Ve). LV volumes and LVEF were similar between groups. However, LV mass increased significantly and progressively (LVM/Ht2.7, in g/m2.7: 34.9 ± 6.7, 41.0 ± 9.5, 46.3 ± 11.0, P < 0.001); LV relaxation decreased progressively (Veglobal′, in cm/s: 13.5 ± 2.8, 12.1 ± 3.0, 10.5 ± 2.2, P < 0.001) from Absent to Pre-Metabolic Syndrome to Metabolic Syndrome groups, respectively. Multiple variable analyses showed that diastolic blood pressure, waist circumference, and triglyceride levels were independent predictors of Ve after adjustment for LV mass. Conclusion: Patients with metabolic syndrome have LV diastolic dysfunction independent of LV mass. These functional abnormalities may partially explain the increased cardiovascular morbidity and mortality associated with metabolic syndrome.
KW - Diastolic function
KW - Echocardiography
KW - Hypertension
KW - Metabolic syndrome
KW - Obesity
KW - Tissue doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=34250866507&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehl526
DO - 10.1093/eurheartj/ehl526
M3 - Article
C2 - 17311827
AN - SCOPUS:34250866507
SN - 0195-668X
VL - 28
SP - 553
EP - 559
JO - European heart journal
JF - European heart journal
IS - 5
ER -