Metabolic storage diseases: Amyloidosis

Elizabeth M. Brunt; Dina G. Tiniakos

doi:10.1016/j.cld.2004.06.009

Metabolic storage diseases: Amyloidosis

Elizabeth M. Brunt, Dina G. Tiniakos

Anatomic and Molecular Pathology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis. Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy.

Original language	English
Pages (from-to)	915-930
Number of pages	16
Journal	Clinics in Liver Disease
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.cld.2004.06.009
State	Published - Nov 1 2004

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10.1016/j.cld.2004.06.009

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abstract = "This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis. Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy.",

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AB - This article provides an overview of the current concepts in pathogenesis, epidemiology, clinical significance, and treatment options for amyloidosis. Emphasis is given to hepatic amyloidosis, which ranges from a clinically insignificant histologic curiosity to a harbinger of widespread disease accompanied by a poor prognosis. Clinical characteristics and clues to the diagnosis are discussed as well as the importance of histologic confirmation and the controversy surrounding liver biopsy.

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