TY - JOUR
T1 - Metabolic regulation of NK cell antiviral functions during cytomegalovirus infection
AU - Cimpean, Maria
AU - Cooper, Megan A.
N1 - Publisher Copyright:
© 2023 The Author(s).
PY - 2023/5
Y1 - 2023/5
N2 - Natural killer (NK) cells quickly mount cytotoxic responses, produce cytokines, and proliferate in response to infected or transformed cells. Moreover, they can develop memory, with enhanced effector responses following activation, in some cases with antigen specificity. To optimally execute these functions, NK cells undergo metabolic reprogramming. Here, we discuss the interplay between metabolism and NK cell function in the context of viral infections. We review findings supporting metabolic regulation of NK cell effector functions, with a focus on NK cell antiviral infection in the context of cytomegalovirus in the mouse (MCMV) and human (HCMV).
AB - Natural killer (NK) cells quickly mount cytotoxic responses, produce cytokines, and proliferate in response to infected or transformed cells. Moreover, they can develop memory, with enhanced effector responses following activation, in some cases with antigen specificity. To optimally execute these functions, NK cells undergo metabolic reprogramming. Here, we discuss the interplay between metabolism and NK cell function in the context of viral infections. We review findings supporting metabolic regulation of NK cell effector functions, with a focus on NK cell antiviral infection in the context of cytomegalovirus in the mouse (MCMV) and human (HCMV).
KW - cytokines
KW - cytomegalovirus infection
KW - cytotoxicity
KW - interferon gamma
KW - memory
KW - metabolism
KW - natural killer cells
KW - proliferation
UR - http://www.scopus.com/inward/record.url?scp=85159543164&partnerID=8YFLogxK
U2 - 10.1093/jleuko/qiad018
DO - 10.1093/jleuko/qiad018
M3 - Review article
C2 - 36843434
AN - SCOPUS:85159543164
SN - 0741-5400
VL - 113
SP - 525
EP - 534
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 5
ER -