Metabolic regulation of liver regeneration

Jiansheng Huang, David A. Rudnick

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The liver is well known to regenerate from hepatic injury, and the signals that control this process have been extensively studied. Such investigations reveal several principles governing the regenerative response and identify many signaling pathways as regulated during and essential for normal regeneration. Nevertheless, the earliest events that stimulate liver regeneration as well as the distal signals that terminate this response remain incompletely understood. Moreover, the ultimate goal of such research, i.e. translation of mechanism-based proregenerative interventions into new treatments for human liver diseases, has not yet been achieved. Recent studies suggest that alterations in metabolism generate important signals that regulate regenerative hepatocellular proliferation. This chapter provides an overview of the data in support of a "metabolic model" of liver regeneration and considers the clinical implications and opportunities for further study suggested by those results.

Original languageEnglish
Title of host publicationSignaling Pathways in Liver Diseases
Subtitle of host publicationThird Edition
PublisherWiley Blackwell
Pages174-185
Number of pages12
ISBN (Electronic)9781118663387
ISBN (Print)9781118663394
DOIs
StatePublished - Sep 28 2015

Keywords

  • Acute liver failure
  • Epigenetics
  • Histone acetylation
  • Liver regeneration
  • Metabolism
  • Partial hepatectomy

Fingerprint Dive into the research topics of 'Metabolic regulation of liver regeneration'. Together they form a unique fingerprint.

  • Cite this

    Huang, J., & Rudnick, D. A. (2015). Metabolic regulation of liver regeneration. In Signaling Pathways in Liver Diseases: Third Edition (pp. 174-185). Wiley Blackwell. https://doi.org/10.1002/9781118663387.ch13