Metabolic model guided strain design of cyanobacteria

John I. Hendry, Anindita Bandyopadhyay, Shyam Srinivasan, Himadri B. Pakrasi, Costas D. Maranas

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


Cyanobacteria are oxygenic photoautotrophs that serve as potential platforms for the production of biochemicals from cheap and renewable raw materials – sunlight, water, and carbon dioxide. Systems level analysis of the metabolic network of these organisms could enable the successful engineering of these organisms for the enhanced production of target chemicals. Metabolic modeling techniques including both stoichiometric and kinetic modeling with a genome-wide coverage enable a global assessment of metabolic capabilities. Recent studies guided by such modeling techniques have engineered strains for the enhanced production of valuable chemicals such as ethanol, n-butanol, 1,3-propanediol, glycerol, limonene, and isoprene from CO2.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalCurrent Opinion in Biotechnology
StatePublished - Aug 2020


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