Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans

Kim H.H. Liss, Andrew J. Lutkewitte, Terri Pietka, Brian N. Finck, Michael Franczyk, Jun Yoshino, Samuel Klein, Angela M. Hall

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglyc-erol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate step in triglyceride synthesis. However, little is known about MGAT activity in adipocytes, which are believed to rely primarily on another pathway for triglyceride synthesis. We show that expression of the gene that encodes MGAT1 is robustly induced during adipocyte differentiation and that its expression is suppressed in fat of genetically-obese mice and metabolically-abnormal obese human subjects. Interestingly, MGAT1 expression is also reduced in physiologic contexts where lipolysis is high. Moreover, knockdown or knockout of MGAT1 in adipocytes leads to higher rates of basal adipocyte lipolysis. Collectively, these data suggest that MGAT1 activity may play a role in regulating basal adipocyte FFA retention.—Liss, K. H. H., A. J. Lutkewitte, T. Pietka, B. N. Finck, M. Franczyk, J. Yoshino, S. Klein, and A. M. Hall. Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.

Original languageEnglish
Pages (from-to)1630-1639
Number of pages10
JournalJournal of lipid research
Volume59
Issue number9
DOIs
StatePublished - 2018

Fingerprint

Dive into the research topics of 'Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans'. Together they form a unique fingerprint.

Cite this