TY - JOUR
T1 - Metabolic fibroblast growth factors (FGFs)
T2 - Mediators of energy homeostasis
AU - Markan, Kathleen R.
AU - Potthoff, Matthew J.
N1 - Funding Information:
We thank Teresa Ruggle for assistance with graphic design. This work was supported by an American Diabetes Association Junior Faculty Award 7-13-JF-49 and the National Institutes of Health (NIH) ( R01DK106104 ) to M.J.P., and NIH F32DK102347 to K.R.M.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
AB - The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
KW - FGF1
KW - FGF15
KW - FGF19
KW - FGF21
KW - Metabolism
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84967146023&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2015.09.021
DO - 10.1016/j.semcdb.2015.09.021
M3 - Review article
C2 - 26428296
AN - SCOPUS:84967146023
VL - 53
SP - 85
EP - 93
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
ER -