Metabolic dysfunction in arthritis

Ali Mobasheri; Carolyn A. Bondy; Kelle Moley; Alexandrina Ferreira Mendes; Susana Carvalho Rosa; Stephen M. Richardson; Judith A. Hoyland; Richard Barrett-Jolley; Mehdi Shakibaei

doi:10.1007/978-3-540-78899-7_4

Metabolic dysfunction in arthritis

Ali Mobasheri, Carolyn A. Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen M. Richardson, Judith A. Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei

Department of Obstetrics & Gynecology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Healthy bones and joints depend on a normally functioning endocrine system. It is a fact of clinical significance that excess IGF-I and growth hormone (GH) causes major joint pathology (Stavrou and Kleinberg 2001). Endocrine disorders not only affect soft connective tissues but also implicate load-bearing musculoskeletal structures including bone, cartilage, synovium, tendon, and ligament. Damage to soft connective tissue and associated innervation is a hallmark of acromegaly, hypothyroidism,and diabetes mellitus (Liote and Orcel 2000). Acromegaly normally presents with quite severe arthritis involving degeneration of the spine and articular cartilage in peripheral joints (Stavrou and Kleinberg 2001). Severe diabetes mellitus increases the risk of neuroarthropathy as a direct result of infection, neuropathy, and vasculopathy. Pituitary tumors can have manifestations similar to rheumatological disease and may cause connective tissue disorders as a result of overproduction or deficiencies of pituitary hormones (Stavrou and Kleinberg 2001). Excessive GH production by the pituitary gland causes cartilage destruction. GH deficiency on the other hand increases the risk of bone fractures.

Original language	English
Title of host publication	Facilitative Glucose Transporters in Articular Chondrocytes
Subtitle of host publication	Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok
Editors	Ali Mobasheri, Carolyn Bondy, Kelle Moley, Alexandrina Ferreira Mendes, Susana Carvalho Rosa, Stephen Richardson, Judith Hoyland, Richard Barrett-Jolley, Mehdi Shakibaei
Pages	17-19
Number of pages	3
DOIs	https://doi.org/10.1007/978-3-540-78899-7_4
State	Published - 2008

Publication series

Name	Advances in Anatomy Embryology and Cell Biology
Volume	200
ISSN (Print)	0301-5556

Access to Document

10.1007/978-3-540-78899-7_4

Cite this

Mobasheri, A., Bondy, C. A., Moley, K., Mendes, A. F., Rosa, S. C., Richardson, S. M., Hoyland, J. A., Barrett-Jolley, R., & Shakibaei, M. (2008). Metabolic dysfunction in arthritis. In A. Mobasheri, C. Bondy, K. Moley, A. Ferreira Mendes, S. Carvalho Rosa, S. Richardson, J. Hoyland, R. Barrett-Jolley, & M. Shakibaei (Eds.), Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok (pp. 17-19). (Advances in Anatomy Embryology and Cell Biology; Vol. 200). https://doi.org/10.1007/978-3-540-78899-7_4

Mobasheri, Ali ; Bondy, Carolyn A. ; Moley, Kelle et al. / Metabolic dysfunction in arthritis. Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. editor / Ali Mobasheri ; Carolyn Bondy ; Kelle Moley ; Alexandrina Ferreira Mendes ; Susana Carvalho Rosa ; Stephen Richardson ; Judith Hoyland ; Richard Barrett-Jolley ; Mehdi Shakibaei. 2008. pp. 17-19 (Advances in Anatomy Embryology and Cell Biology).

@inbook{ecc56bbb342d4cb98db20615cc669f1c,

title = "Metabolic dysfunction in arthritis",

abstract = "Healthy bones and joints depend on a normally functioning endocrine system. It is a fact of clinical significance that excess IGF-I and growth hormone (GH) causes major joint pathology (Stavrou and Kleinberg 2001). Endocrine disorders not only affect soft connective tissues but also implicate load-bearing musculoskeletal structures including bone, cartilage, synovium, tendon, and ligament. Damage to soft connective tissue and associated innervation is a hallmark of acromegaly, hypothyroidism,and diabetes mellitus (Liote and Orcel 2000). Acromegaly normally presents with quite severe arthritis involving degeneration of the spine and articular cartilage in peripheral joints (Stavrou and Kleinberg 2001). Severe diabetes mellitus increases the risk of neuroarthropathy as a direct result of infection, neuropathy, and vasculopathy. Pituitary tumors can have manifestations similar to rheumatological disease and may cause connective tissue disorders as a result of overproduction or deficiencies of pituitary hormones (Stavrou and Kleinberg 2001). Excessive GH production by the pituitary gland causes cartilage destruction. GH deficiency on the other hand increases the risk of bone fractures.",

author = "Ali Mobasheri and Bondy, {Carolyn A.} and Kelle Moley and Mendes, {Alexandrina Ferreira} and Rosa, {Susana Carvalho} and Richardson, {Stephen M.} and Hoyland, {Judith A.} and Richard Barrett-Jolley and Mehdi Shakibaei",

year = "2008",

doi = "10.1007/978-3-540-78899-7_4",

language = "English",

isbn = "9783540788980",

series = "Advances in Anatomy Embryology and Cell Biology",

pages = "17--19",

editor = "Ali Mobasheri and Carolyn Bondy and Kelle Moley and {Ferreira Mendes}, Alexandrina and {Carvalho Rosa}, Susana and Stephen Richardson and Judith Hoyland and Richard Barrett-Jolley and Mehdi Shakibaei",

booktitle = "Facilitative Glucose Transporters in Articular Chondrocytes",

}

Mobasheri, A, Bondy, CA, Moley, K, Mendes, AF, Rosa, SC, Richardson, SM, Hoyland, JA, Barrett-Jolley, R & Shakibaei, M 2008, Metabolic dysfunction in arthritis. in A Mobasheri, C Bondy, K Moley, A Ferreira Mendes, S Carvalho Rosa, S Richardson, J Hoyland, R Barrett-Jolley & M Shakibaei (eds), Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. Advances in Anatomy Embryology and Cell Biology, vol. 200, pp. 17-19. https://doi.org/10.1007/978-3-540-78899-7_4

Metabolic dysfunction in arthritis. / Mobasheri, Ali; Bondy, Carolyn A.; Moley, Kelle et al.
Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. ed. / Ali Mobasheri; Carolyn Bondy; Kelle Moley; Alexandrina Ferreira Mendes; Susana Carvalho Rosa; Stephen Richardson; Judith Hoyland; Richard Barrett-Jolley; Mehdi Shakibaei. 2008. p. 17-19 (Advances in Anatomy Embryology and Cell Biology; Vol. 200).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Metabolic dysfunction in arthritis

AU - Mobasheri, Ali

AU - Bondy, Carolyn A.

AU - Moley, Kelle

AU - Mendes, Alexandrina Ferreira

AU - Rosa, Susana Carvalho

AU - Richardson, Stephen M.

AU - Hoyland, Judith A.

AU - Barrett-Jolley, Richard

AU - Shakibaei, Mehdi

PY - 2008

Y1 - 2008

N2 - Healthy bones and joints depend on a normally functioning endocrine system. It is a fact of clinical significance that excess IGF-I and growth hormone (GH) causes major joint pathology (Stavrou and Kleinberg 2001). Endocrine disorders not only affect soft connective tissues but also implicate load-bearing musculoskeletal structures including bone, cartilage, synovium, tendon, and ligament. Damage to soft connective tissue and associated innervation is a hallmark of acromegaly, hypothyroidism,and diabetes mellitus (Liote and Orcel 2000). Acromegaly normally presents with quite severe arthritis involving degeneration of the spine and articular cartilage in peripheral joints (Stavrou and Kleinberg 2001). Severe diabetes mellitus increases the risk of neuroarthropathy as a direct result of infection, neuropathy, and vasculopathy. Pituitary tumors can have manifestations similar to rheumatological disease and may cause connective tissue disorders as a result of overproduction or deficiencies of pituitary hormones (Stavrou and Kleinberg 2001). Excessive GH production by the pituitary gland causes cartilage destruction. GH deficiency on the other hand increases the risk of bone fractures.

AB - Healthy bones and joints depend on a normally functioning endocrine system. It is a fact of clinical significance that excess IGF-I and growth hormone (GH) causes major joint pathology (Stavrou and Kleinberg 2001). Endocrine disorders not only affect soft connective tissues but also implicate load-bearing musculoskeletal structures including bone, cartilage, synovium, tendon, and ligament. Damage to soft connective tissue and associated innervation is a hallmark of acromegaly, hypothyroidism,and diabetes mellitus (Liote and Orcel 2000). Acromegaly normally presents with quite severe arthritis involving degeneration of the spine and articular cartilage in peripheral joints (Stavrou and Kleinberg 2001). Severe diabetes mellitus increases the risk of neuroarthropathy as a direct result of infection, neuropathy, and vasculopathy. Pituitary tumors can have manifestations similar to rheumatological disease and may cause connective tissue disorders as a result of overproduction or deficiencies of pituitary hormones (Stavrou and Kleinberg 2001). Excessive GH production by the pituitary gland causes cartilage destruction. GH deficiency on the other hand increases the risk of bone fractures.

UR - http://www.scopus.com/inward/record.url?scp=51049112307&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-78899-7_4

DO - 10.1007/978-3-540-78899-7_4

M3 - Chapter

AN - SCOPUS:51049112307

SN - 9783540788980

T3 - Advances in Anatomy Embryology and Cell Biology

SP - 17

EP - 19

BT - Facilitative Glucose Transporters in Articular Chondrocytes

A2 - Mobasheri, Ali

A2 - Bondy, Carolyn

A2 - Moley, Kelle

A2 - Ferreira Mendes, Alexandrina

A2 - Carvalho Rosa, Susana

A2 - Richardson, Stephen

A2 - Hoyland, Judith

A2 - Barrett-Jolley, Richard

A2 - Shakibaei, Mehdi

ER -

Mobasheri A, Bondy CA, Moley K, Mendes AF, Rosa SC, Richardson SM et al. Metabolic dysfunction in arthritis. In Mobasheri A, Bondy C, Moley K, Ferreira Mendes A, Carvalho Rosa S, Richardson S, Hoyland J, Barrett-Jolley R, Shakibaei M, editors, Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics, Growth Factors and Pro-Inflammatory Cytok. 2008. p. 17-19. (Advances in Anatomy Embryology and Cell Biology). doi: 10.1007/978-3-540-78899-7_4

Metabolic dysfunction in arthritis

Abstract

Publication series

Access to Document

Other files and links

Fingerprint

Cite this