Metabolic Determinants of Mitochondrial Function in Oocytes

Emily A. Seidler, Kelle H. Moley

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Mitochondrial production of cellular energy is essential to oocyte function, zygote development and successful continuation of pregnancy. This review focuses on several key functions of healthy oocyte mitochondria and the effect of pathologic states such as aging, oxidative stress and apoptosis on these functions. The effect of these abnormal conditions is presented in terms of clinical presentations, specifically maternal obesity, diminished ovarian reserve and assisted reproductive technologies.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalSeminars in Reproductive Medicine
Volume33
Issue number6
DOIs
StatePublished - Nov 12 2015

Keywords

  • mitochondrial DNA
  • mitochondrial function
  • mitochondrial transplant
  • oocyte metabolism
  • oocyte quality
  • reactive oxygen species

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