Abstract
Mitochondrial production of cellular energy is essential to oocyte function, zygote development and successful continuation of pregnancy. This review focuses on several key functions of healthy oocyte mitochondria and the effect of pathologic states such as aging, oxidative stress and apoptosis on these functions. The effect of these abnormal conditions is presented in terms of clinical presentations, specifically maternal obesity, diminished ovarian reserve and assisted reproductive technologies.
| Original language | English |
|---|---|
| Pages (from-to) | 396-400 |
| Number of pages | 5 |
| Journal | Seminars in Reproductive Medicine |
| Volume | 33 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 12 2015 |
Keywords
- mitochondrial DNA
- mitochondrial function
- mitochondrial transplant
- oocyte metabolism
- oocyte quality
- reactive oxygen species