Metabolic connections during apoptotic cell engulfment

Claudia Z. Han; Kodi S. Ravichandran

doi:10.1016/j.cell.2011.12.006

Metabolic connections during apoptotic cell engulfment

Claudia Z. Han, Kodi S. Ravichandran

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.

Original language	English
Pages (from-to)	1442-1445
Number of pages	4
Journal	Cell
Volume	147
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2011.12.006
State	Published - Dec 23 2011

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title = "Metabolic connections during apoptotic cell engulfment",

abstract = "Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.",

author = "Han, {Claudia Z.} and Ravichandran, {Kodi S.}",

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AU - Han, Claudia Z.

AU - Ravichandran, Kodi S.

PY - 2011/12/23

Y1 - 2011/12/23

N2 - Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.

AB - Billions of cells die via apoptosis every day and are swiftly removed. When a phagocyte engulfs an apoptotic cell, it essentially doubles its cellular contents, raising the question of how a phagocyte may manage the excess metabolic load. This Minireview discusses phagocyte cellular metabolism, the digestion of the ingested apoptotic cell, and the impact of these processes on engulfment.

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U2 - 10.1016/j.cell.2011.12.006

DO - 10.1016/j.cell.2011.12.006

M3 - Review article

C2 - 22196723

AN - SCOPUS:84455200568

SN - 0092-8674

VL - 147

SP - 1442

EP - 1445

JO - Cell

JF - Cell

IS - 7

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Metabolic connections during apoptotic cell engulfment

Abstract

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