@article{699753ce70444fbbae85ccb8d6be0c31,
title = "Metabolic Biomarkers Assessed with PET/CT Predict Sex-Specific Longitudinal Outcomes in Patients with Diffuse Large B-Cell Lymphoma",
abstract = "In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic altera-tions in metabolism, i.e., obesity. We wanted to determine if visceral fat and tumor glucose uptake with fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) could predict sex-dependent outcomes in patients with diffuse large B-cell lymphoma (DLBCL). We conducted a retrospective analysis of 160 patients (84 males; 76 females) with DLBCL who had imaging at initial staging and after completion of therapy. CT-based relative visceral fat area (rVFA), PET-based SUVmax normalized to lean body mass (SULmax), and end-of-treatment FDG-PET 5PS score were calculated. Increased rVFA at initial staging was an independent predictor of poor OS only in females. At the end of therapy, increase in visceral fat was a significant predictor of poor survival only in females. Combining the change in rVFA and 5PS scores identified a subgroup of females with visceral fat gain and high 5PS with exceptionally poor outcomes. These data suggest that visceral fat and tumor FDG uptake can predict outcomes in DLBCL patients in a sex-specific fashion.",
keywords = "CT, DLBCL, FDG-PET, body composition, glucose metabolism, lymphoma, sex differences, visceral fat",
author = "Shama Jaswal and Vanessa Sanders and Priyanka Pullarkat and Stephanie Teja and Amber Albright and Watkins, {Marcus P.} and Norman Atagu and Ludwig, {Daniel R.} and Joyce Mhlanga and Mellnick, {Vincent M.} and Peterson, {Linda R.} and Bartlett, {Nancy L.} and Kahl, {Brad S.} and Fehniger, {Todd A.} and Armin Ghobadi and Cashen, {Amanda F.} and Neha Mehta-Shah and Ippolito, {Joseph E.}",
note = "Funding Information: This research was funded by NIH, grant number R21CA242221 (J.E.I.), R00CA218869 (J.E.I.), UL1TR002345 (J.E.I.), K12CA167540 (N.M.S.); Lymphoma Research Foundation, grant number 610181 (N.M.S.); and Barnes Jewish Hospital Foundation (J.E.I.). The authors gratefully acknowledge the Transdisciplinary Research on Energetics and Cancer (TREC) Training Workshop R25CA203650 (PI: Melinda Irwin). Funding Information: Funding: This research was funded by NIH, grant number R21CA242221 (J.E.I.), R00CA218869 (J.E.I.), UL1TR002345 (J.E.I.), K12CA167540 (N.M.S.); Lymphoma Research Foundation, grant number 610181 (N.M.S.); and Barnes Jewish Hospital Foundation (J.E.I.). The authors gratefully acknowledge the Transdisciplinary Research on Energetics and Cancer (TREC) Training Workshop R25CA203650 (PI: Melinda Irwin). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = jun,
day = "1",
doi = "10.3390/cancers14122932",
language = "English",
volume = "14",
journal = "Cancers",
issn = "2072-6694",
number = "12",
}