TY - JOUR
T1 - Metabolic aspects of surgical subcutaneous fat removal
T2 - An umbrella review and implications for future research
AU - Badran, Saif
AU - Doi, Suhail A.
AU - Hamdi, Moustapha
AU - Hammouda, Atalla
AU - Alharami, Sara
AU - Clark, Justin
AU - Musa, Omran A.H.
AU - Abou-Samra, Abdul Badi
AU - Habib, Abdella M.
N1 - Publisher Copyright:
© 2022 Badran et al.
PY - 2023/3/16
Y1 - 2023/3/16
N2 - Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve physical appearance. The need for SSFR is further exacerbated because of the global rise in the number of bariatric surgeries, which is currently the single most durable intervention for mitigating obesity. Fat tissue is now recognized as a vital endocrine organ that produces several bioactive proteins. Thus, SSFR-mediated weight (fat) loss can potentially have significant metabolic effects; however, currently, there is no consensus on this issue. This review focuses on the metabolic sequelae after SSFR interventions for dealing with cosmetic body appearance. Data were extracted from existing systematic reviews and the diversity of possible metabolic changes after SSFR are reported along with gaps in the knowledge and future directions for research and practice. We conclude that there is a potential for metabolic sequelae after SSFR interventions and their clinical implications for the safety of the procedures as well as for our understanding of subcutaneous adipose tissue biology and insulin resistance are discussed.
AB - Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve physical appearance. The need for SSFR is further exacerbated because of the global rise in the number of bariatric surgeries, which is currently the single most durable intervention for mitigating obesity. Fat tissue is now recognized as a vital endocrine organ that produces several bioactive proteins. Thus, SSFR-mediated weight (fat) loss can potentially have significant metabolic effects; however, currently, there is no consensus on this issue. This review focuses on the metabolic sequelae after SSFR interventions for dealing with cosmetic body appearance. Data were extracted from existing systematic reviews and the diversity of possible metabolic changes after SSFR are reported along with gaps in the knowledge and future directions for research and practice. We conclude that there is a potential for metabolic sequelae after SSFR interventions and their clinical implications for the safety of the procedures as well as for our understanding of subcutaneous adipose tissue biology and insulin resistance are discussed.
KW - Surgical subcutaneous fat removal (SSFR)
KW - adipokines
KW - body contouring surgery
KW - inflammation
KW - insulin resistance
KW - metabolism
UR - http://www.scopus.com/inward/record.url?scp=85150820484&partnerID=8YFLogxK
U2 - 10.17305/bjbms.2022.8175
DO - 10.17305/bjbms.2022.8175
M3 - Review article
C2 - 36200436
AN - SCOPUS:85150820484
SN - 2831-0896
VL - 23
SP - 235
EP - 247
JO - Biomolecules and Biomedicine
JF - Biomolecules and Biomedicine
IS - 1
ER -