Metabolic acidosis and vascular calcification: Using blueprints from bone to map a new venue for vascular research

Z. Al-Aly

doi:10.1038/sj.ki.5002738

Metabolic acidosis and vascular calcification: Using blueprints from bone to map a new venue for vascular research

Z. Al-Aly

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Vascular calcification is an important problem in patients with chronic kidney disease. The pathobiology of vascular calcification is complex and is intricately related to bone remodeling. Mendoza et al. report that experimental metabolic acidosis prevents calcitriol-induced vascular calcification in uremic animals. To fully understand the effect of acidosis on the vasculature, a comprehensive and integrated approach that simultaneously examines the effect of metabolic acidosis on bone and vasculature is needed.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Kidney International
Volume	73
Issue number	4
DOIs	https://doi.org/10.1038/sj.ki.5002738
State	Published - Feb 2008

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10.1038/sj.ki.5002738

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title = "Metabolic acidosis and vascular calcification: Using blueprints from bone to map a new venue for vascular research",

abstract = "Vascular calcification is an important problem in patients with chronic kidney disease. The pathobiology of vascular calcification is complex and is intricately related to bone remodeling. Mendoza et al. report that experimental metabolic acidosis prevents calcitriol-induced vascular calcification in uremic animals. To fully understand the effect of acidosis on the vasculature, a comprehensive and integrated approach that simultaneously examines the effect of metabolic acidosis on bone and vasculature is needed.",

author = "Z. Al-Aly",

year = "2008",

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pages = "377--379",

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T2 - Using blueprints from bone to map a new venue for vascular research

AU - Al-Aly, Z.

PY - 2008/2

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N2 - Vascular calcification is an important problem in patients with chronic kidney disease. The pathobiology of vascular calcification is complex and is intricately related to bone remodeling. Mendoza et al. report that experimental metabolic acidosis prevents calcitriol-induced vascular calcification in uremic animals. To fully understand the effect of acidosis on the vasculature, a comprehensive and integrated approach that simultaneously examines the effect of metabolic acidosis on bone and vasculature is needed.

AB - Vascular calcification is an important problem in patients with chronic kidney disease. The pathobiology of vascular calcification is complex and is intricately related to bone remodeling. Mendoza et al. report that experimental metabolic acidosis prevents calcitriol-induced vascular calcification in uremic animals. To fully understand the effect of acidosis on the vasculature, a comprehensive and integrated approach that simultaneously examines the effect of metabolic acidosis on bone and vasculature is needed.

UR - https://www.scopus.com/pages/publications/38749084551

U2 - 10.1038/sj.ki.5002738

DO - 10.1038/sj.ki.5002738

M3 - Comment/debate

C2 - 18235519

AN - SCOPUS:38749084551

SN - 0085-2538

VL - 73

SP - 377

EP - 379

JO - Kidney International

JF - Kidney International

IS - 4

ER -

Metabolic acidosis and vascular calcification: Using blueprints from bone to map a new venue for vascular research

Abstract

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