Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Wanqing Wen, Wei Zheng, Yukinori Okada, Fumihiko Takeuchi, Yasuharu Tabara, Joo Yeon Hwang, Rajkumar Dorajoo, Huaixing Li, Fuu Jen Tsai, Xiaobo Yang, Jiang He, Ying Wu, Meian He, Yi Zhang, Jun Liang, Xiuqing Guo, Wayne H.uey Herng Sheu, Ryan Delahanty, Xingyi Guo, Michiaki KuboKen Yamamoto, Takayoshi Ohkubo, Min J.in Go, Jian J.un Liu, Wei Gan, Ching Chu Chen, Yong Gao, Shengxu Li, Nanette R. Lee, Chen Wu, Xueya Zhou, Huaidong Song, Jie Yao, I. Te Lee, Jirong Long, Tatsuhiko Tsunoda, Koichi Akiyama, Naoyuki Takashima, Yoon S.hin Cho, Rick T.h. Ong, Ling Lu, Chien Hsiun Chen, Aihua Tan, Treva K. Rice, Linda S. Adair, Lixuan Gui, Matthew Allison, Wen Jane Lee, Qiuyin Cai, Minoru Isomura, Satoshi Umemura, Young J.in Kim, Mark Seielstad, James Hixson, Yong Bing Xiang, Masato Isono, Bong Jo Kim, Xueling Sim, Wei Lu, Toru Nabika, Juyoung Lee, Wei Yen Lim, Yu Tang Gao, Ryoichi Takayanagi, Dae Hee Kang, Tien Y.in Wong, Chao A.gnes Hsiung, I. Chien Wu, Jyh Ming J.immy Juang, Jiajun Shi, Bo Y.oul Choi, Tin Aung, Frank Hu, Mi K.yung Kim, Wei Y.en Lim, Tzung Dao Wang, Min Ho Shin, Jeannette Lee, Bu Tian Ji, Young Hoon Lee, Terri L. Young, Dong H.oon Shin, Byung Yeol Chun, Myeong Chan Cho, Bok Ghee Han, Chii Min Hwu, Themistocles L. Assimes, Devin Absher, Xiaofei Yan, Eric Kim, Jane Z. Kuo, Soonil Kwon, Kent D. Taylor, Yii Der I. Chen, Jerome I. Rotter, Lu Qi, Dingliang Zhu, Tangchun Wu, Karen L. Mohlke, Dongfeng Gu, Zengnan Mo, Jer Yuarn Wu, Xu Lin, Tetsuro Miki, E. Shyong Tai, Jong Young Lee, Norihiro Kato, Xiao Ou Shu, Toshihiro Tanaka

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.

Original languageEnglish
Pages (from-to)5492-5504
Number of pages13
JournalHuman molecular genetics
Volume23
Issue number20
DOIs
StatePublished - Oct 15 2014
Externally publishedYes

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