TY - JOUR
T1 - Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
AU - The MAGIC investigators
AU - The GIANT Consortium
AU - Ng, Maggie C.Y.
AU - Shriner, Daniel
AU - Chen, Brian H.
AU - Li, Jiang
AU - Chen, Wei Min
AU - Guo, Xiuqing
AU - Liu, Jiankang
AU - Bielinski, Suzette J.
AU - Yanek, Lisa R.
AU - Nalls, Michael A.
AU - Comeau, Mary E.
AU - Rasmussen-Torvik, Laura J.
AU - Jensen, Richard A.
AU - Evans, Daniel S.
AU - Sun, Yan V.
AU - An, Ping
AU - Patel, Sanjay R.
AU - Lu, Yingchang
AU - Long, Jirong
AU - Armstrong, Loren L.
AU - Wagenknecht, Lynne
AU - Yang, Lingyao
AU - Snively, Beverly M.
AU - Palmer, Nicholette D.
AU - Mudgal, Poorva
AU - Langefeld, Carl D.
AU - Keene, Keith L.
AU - Freedman, Barry I.
AU - Mychaleckyj, Josyf C.
AU - Nayak, Uma
AU - Raffel, Leslie J.
AU - Goodarzi, Mark O.
AU - Chen, Y. D.Ida
AU - Taylor, Herman A.
AU - Correa, Adolfo
AU - Sims, Mario
AU - Couper, David J.
AU - Pankow, James S.
AU - Boerwinkle, Eric
AU - Adeyemo, Adebowale
AU - Doumatey, Ayo
AU - Chen, Guanjie
AU - Mathias, Rasika A.
AU - Vaidya, Dhananjay
AU - Singleton, Andrew B.
AU - Zonderman, Alan B.
AU - Igo, Robert P.
AU - Sedor, John R.
AU - Kraja, Aldi
AU - Province, Michael A.
N1 - Publisher Copyright:
© 2014.
PY - 2014/8/7
Y1 - 2014/8/7
N2 - Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15×10−94−8, odds ratio (OR) = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2×10−23 < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.
AB - Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15×10−94−8, odds ratio (OR) = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2×10−23 < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.
UR - http://www.scopus.com/inward/record.url?scp=84946031456&partnerID=8YFLogxK
U2 - 10.1371/journal.pgen.1004517
DO - 10.1371/journal.pgen.1004517
M3 - Article
C2 - 25102180
AN - SCOPUS:84946031456
SN - 1553-7390
VL - 10
JO - PLoS genetics
JF - PLoS genetics
IS - 8
M1 - e1004517
ER -