TY - JOUR
T1 - Meta-analysis of genetic linkage to quantitative trait loci with study- specific covariates
T2 - A mixed-effects model
AU - Gu, Chi
AU - Province, M.
AU - Rao, D. C.
PY - 1999
Y1 - 1999
N2 - A method of meta-analysis was used to combine summary linkage information from four hypothetical study groups simulated in GAW11 Problem 2 with no knowledge of the answer. Five replication studies were selected from each group, and a pool of 20 primary studies was used for combining. Using a mixed-effects model with the among-study variation as random effects, we pooled results from all the 20 studies and detected strong linkage signals on chromosome 5 at D5G38 and on chromosome 3 near D3G45. We also found suggestive signals on chromosome 1 near D1G9, and possible interaction of D1G24 with the selection for the severe form of the disease.
AB - A method of meta-analysis was used to combine summary linkage information from four hypothetical study groups simulated in GAW11 Problem 2 with no knowledge of the answer. Five replication studies were selected from each group, and a pool of 20 primary studies was used for combining. Using a mixed-effects model with the among-study variation as random effects, we pooled results from all the 20 studies and detected strong linkage signals on chromosome 5 at D5G38 and on chromosome 3 near D3G45. We also found suggestive signals on chromosome 1 near D1G9, and possible interaction of D1G24 with the selection for the severe form of the disease.
KW - Quantitative trait locus mapping
KW - Sib-pairs method
UR - http://www.scopus.com/inward/record.url?scp=0032752078&partnerID=8YFLogxK
U2 - 10.1002/gepi.1370170797
DO - 10.1002/gepi.1370170797
M3 - Article
C2 - 10597499
AN - SCOPUS:0032752078
SN - 0741-0395
VL - 17
SP - S599-S604
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - SUPPL. 1
ER -