TY - JOUR
T1 - Meta-analyses of genome-wide association data hold new promise for addiction genetics
AU - Agrawal, Arpana
AU - Edenberg, Howard J.
AU - Gelernter, Joel
N1 - Funding Information:
PGC is funded by MH094421. We thank the National Institute on Drug Abuse for supporting us via an administrative supplement and the National Institute on Alcohol Abuse and Alcoholism for support via the Collaborative Study on the Genetics of Alcoholism (AA008401). Arpana Agrawal acknowledges K02DA32573 and Joel Gelernter acknowledges R01DA12690.
Publisher Copyright:
© 2016, Alcohol Research Documentation Inc. All right reserved.
PY - 2016/9
Y1 - 2016/9
N2 - Meta-analyses of genome-wide association study data have begun to lead to promising new discoveries for behavioral and psychiatrically relevant phenotypes (e.g., schizophrenia, educational attainment). We outline how this methodology can similarly lead to novel discoveries in genomic studies of substance use disorders, and discuss challenges that will need to be overcome to accomplish this goal. We illustrate our approach with the work of the newly established Substance Use Disorders workgroup of the Psychiatric Genomics Consortium.
AB - Meta-analyses of genome-wide association study data have begun to lead to promising new discoveries for behavioral and psychiatrically relevant phenotypes (e.g., schizophrenia, educational attainment). We outline how this methodology can similarly lead to novel discoveries in genomic studies of substance use disorders, and discuss challenges that will need to be overcome to accomplish this goal. We illustrate our approach with the work of the newly established Substance Use Disorders workgroup of the Psychiatric Genomics Consortium.
UR - http://www.scopus.com/inward/record.url?scp=84986277514&partnerID=8YFLogxK
U2 - 10.15288/jsad.2016.77.676
DO - 10.15288/jsad.2016.77.676
M3 - Article
C2 - 27588522
AN - SCOPUS:84986277514
SN - 1937-1888
VL - 77
SP - 676
EP - 680
JO - Journal of Studies on Alcohol and Drugs
JF - Journal of Studies on Alcohol and Drugs
IS - 5
ER -