MET mutation causes muscular dysplasia and arthrogryposis

Hang Zhou, Chengjie Lian, Tingting Wang, Xiaoming Yang, Caixia Xu, Deying Su, Shuhui Zheng, Xiangyu Huang, Zhiheng Liao, Taifeng Zhou, Xianjian Qiu, Yuyu Chen, Bo Gao, Yongyong Li, Xudong Wang, Guoling You, Qihua Fu, Christina Gurnett, Dongsheng Huang, Peiqiang Su

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Arthrogryposis is a group of phenotypically and genetically heterogeneous disorders characterized by congenital contractures of two or more parts of the body; the pathogenesis and the causative genes of arthrogryposis remain undetermined. We examined a four-generation arthrogryposis pedigree characterized by camptodactyly, limited forearm supination, and loss of myofibers in the forearms and hands. By using whole-exome sequencing, we confirmed MET p.Y1234C mutation to be responsible for arthrogryposis in this pedigree. MET p.Y1234C mutation caused the failure of activation of MET tyrosine kinase. A Met p.Y1232C mutant mouse model was established. The phenotypes of homozygous mice included embryonic lethality and complete loss of muscles that originated from migratory precursors. Heterozygous mice were born alive and showed reduction of the number of myofibers in both appendicular and axial muscles. Defective migration of muscle progenitor cells and impaired proliferation of secondary myoblasts were proven to be responsible for the skeletal muscle dysplasia of mutant mice. Overall, our study shows MET to be a causative gene of arthrogryposis and MET mutation could cause skeletal muscle dysplasia in human beings.

Original languageEnglish
Article numbere9709
JournalEMBO Molecular Medicine
Volume11
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • MET
  • arthrogryposis
  • muscle development
  • muscular dysplasia
  • whole-exome sequence

Fingerprint Dive into the research topics of 'MET mutation causes muscular dysplasia and arthrogryposis'. Together they form a unique fingerprint.

  • Cite this

    Zhou, H., Lian, C., Wang, T., Yang, X., Xu, C., Su, D., Zheng, S., Huang, X., Liao, Z., Zhou, T., Qiu, X., Chen, Y., Gao, B., Li, Y., Wang, X., You, G., Fu, Q., Gurnett, C., Huang, D., & Su, P. (2019). MET mutation causes muscular dysplasia and arthrogryposis. EMBO Molecular Medicine, 11(3), [e9709]. https://doi.org/10.15252/emmm.201809709