TY - JOUR
T1 - Mesothelin and kidney function-Analysis of relationship and implications for mesothelioma screening
AU - Boudville, Neil
AU - Paul, Rohan
AU - Robinson, Bruce W.S.
AU - Creaney, Jenette
N1 - Funding Information:
We would like to thank Deborah Yeoman, Ling Lei, Yvonne Demelker and Hanne Dare, and also the staff of PathWest Laboratory Medicine, Sir Charles Gairdner Hospital and Royal Perth Hospital for their assistance with this study. This work was supported in part by the National Health and Medical Research Council of Australia and the Insurance Commission of Western Australia, these bodies had no role in the study design, implementation or manuscript preparation.
Funding Information:
BR has previously received grant support from Fujirecbio Diagnostics Incorporated (FDI) (2004–2006). BR and JC have previously received honoraria from FDI (2006). NB and RP have no conflicts to declare.
PY - 2011/9
Y1 - 2011/9
N2 - Purpose: Malignant mesothelioma (MM) carries a poor prognosis and remains a major public health issue in many countries. Outcomes may be improved with earlier detection and this justifies screening the at-risk asbestos-exposed population. Soluble mesothelin is a potential biomarker for MM, but it has been observed to be elevated in patients with reduced kidney function. Defining the relationship between mesothelin concentrations and kidney function will allow more accurate interpretation of this assay. Materials and methods: A cross-sectional study consisting of 144 patients with chronic kidney disease (CKD) was conducted at Sir Charles Gairdner Hospital and Royal Perth Hospital in Western Australia. Only patients with CKD stages II-V were recruited while those with a history of renal transplant, dialysis, or malignancy were excluded. Serum and urine mesothelin and creatinine concentrations were determined. Results: There were 33, 49, 31 and 31 patients in CKD stages II, III, IV and V, respectively recruited. Serum mesothelin increased significantly with increasing serum creatinine (p< 0.0001), and worsening stage of CKD (p< 0.0001). A significant correlation between urine mesothelin to creatinine ratio and serum mesothelin concentration was detected (p = 0.002). No significant difference was found in urine mesothelin to creatinine ratios across the four CKD stage groups. Conclusion: Serum mesothelin concentration is elevated in individuals with renal impairment. Renal function should therefore be taken into account during interpretation of this assay.
AB - Purpose: Malignant mesothelioma (MM) carries a poor prognosis and remains a major public health issue in many countries. Outcomes may be improved with earlier detection and this justifies screening the at-risk asbestos-exposed population. Soluble mesothelin is a potential biomarker for MM, but it has been observed to be elevated in patients with reduced kidney function. Defining the relationship between mesothelin concentrations and kidney function will allow more accurate interpretation of this assay. Materials and methods: A cross-sectional study consisting of 144 patients with chronic kidney disease (CKD) was conducted at Sir Charles Gairdner Hospital and Royal Perth Hospital in Western Australia. Only patients with CKD stages II-V were recruited while those with a history of renal transplant, dialysis, or malignancy were excluded. Serum and urine mesothelin and creatinine concentrations were determined. Results: There were 33, 49, 31 and 31 patients in CKD stages II, III, IV and V, respectively recruited. Serum mesothelin increased significantly with increasing serum creatinine (p< 0.0001), and worsening stage of CKD (p< 0.0001). A significant correlation between urine mesothelin to creatinine ratio and serum mesothelin concentration was detected (p = 0.002). No significant difference was found in urine mesothelin to creatinine ratios across the four CKD stage groups. Conclusion: Serum mesothelin concentration is elevated in individuals with renal impairment. Renal function should therefore be taken into account during interpretation of this assay.
KW - Glomerular filtration rate
KW - Kidney function
KW - Mesothelin
KW - Mesothelioma
KW - SMRP
UR - http://www.scopus.com/inward/record.url?scp=79960891294&partnerID=8YFLogxK
U2 - 10.1016/j.lungcan.2011.01.011
DO - 10.1016/j.lungcan.2011.01.011
M3 - Article
C2 - 21333373
AN - SCOPUS:79960891294
SN - 0169-5002
VL - 73
SP - 320
EP - 324
JO - Lung Cancer
JF - Lung Cancer
IS - 3
ER -