Mesenteric vasoconstriction in response to hemorrhagic shock

Thomas Toung, Patrick M. Reilly, Katherine C. Fuh, Robert Ferris, Gregory B. Bulkley

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Previous studies indicate that cardiogenic shock (tamponade) in swine produces selective mesenteric ischemia due to disproportionate mesenteric vasospasm mediated primarily by the reninangiotensin axis. Here, we characterized the systemic and mesenteric hemodynamic responses to hypovolemic shock to better understand the neurohumoral mechanisms controlling this response. Varying degrees of hypovolemic shock were produced by graded levels of hemorrhage, from 12.5 to 50% of the calculated blood volume. Systemic and mesenteric pressures and blood flows were measured, and corresponding vascular resistances were calculated. The hemodynamic responses of the mesenteric vascular bed were compared with those of the systemic (nonmesenteric) vasculature. These experiments were then repeated after confirmed blockade either of the α-adrenergic nervous system (phenoxybenzamine), of vasopressin (Manning compound), or of the renin-angiotensin axis (enalapril). Graded levels of hemorrhage produced corresponding graded, reproducible, steady-state levels of systemic hypotension, hypoperfusion, and peripheral vasoconstriction, i.e., hemorrhagic shock. This was associated with disproportionate degrees of mesenteric ischemia due to disproportionate mesenteric vasoconstriction. The selective component of this mesenteric vasoconstrictive response was not attenuated by α-adrenergic blockade nor by vasopressin blockade but was blocked by ablation of the renin-angiotensin axis with enalapril. Like cardiogenic shock, hemorrhagic shock generates selective mesenteric ischemia by producing a disproportionate mesenteric vasospasm that is mediated primarily by the renin-angiotensin axis.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalShock
Volume13
Issue number4
DOIs
StatePublished - Apr 2000

Keywords

  • Angiotensin
  • Mesenteric ischemia
  • Renin
  • Splanchnic circulation
  • Splanchnic vasoconstriction
  • Swine
  • Sympathetic nervous system
  • Vasopressin

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