Mesenchymal stem cell therapy of intestinal disease: Are their effects systemic or localized?

Nicholas A. Manieri, Thaddeus S. Stappenbeck

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Purpose of Review: Stem cell therapy for intestinal diseases is an emerging area in clinical gastroenterology. We will review recent literature regarding mesenchymal stem cells, which have been utilized in preclinical models and are now headed for clinical trials in several gastrointestinal diseases including inflammatory bowel disease. Recent Findings: Important studies over the last 2 years have made significant inroads into understanding the mechanisms of action of these cell types. The two major competing hypotheses are that mesenchymal stem cells home to areas of injury where they repair based on their stem cell activity or that mesenchymal stem cells act as a source of secreted factors that stimulate repair and inhibit inflammation. Summary: Mesenchymal stem cells show promise for therapy in a number of intestinal diseases. Further understanding of their mechanism of action should improve our ability to use them therapeutically.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalCurrent opinion in gastroenterology
Volume27
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • inflammatory bowel disease
  • intestine
  • macrophage
  • mesenchymal stem cell
  • stem cell

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