Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

Carolin J. Teman; Sheryl R. Tripp; Sherrie L. Perkins; Eric J. Duncavage

doi:10.1016/j.leukres.2011.01.032

Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

Carolin J. Teman, Sheryl R. Tripp, Sherrie L. Perkins, Eric J. Duncavage

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47 Scopus citations

Abstract

Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.

Original language	English
Pages (from-to)	689-692
Number of pages	4
Journal	Leukemia Research
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2011.01.032
State	Published - May 2011

Keywords

CLL
Chronic lymphocytic leukemia
MCPyV
Polyomavirus
SLL
Small lymphocytic lymphoma

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10.1016/j.leukres.2011.01.032

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title = "Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma",

abstract = "Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33\% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.",

keywords = "CLL, Chronic lymphocytic leukemia, MCPyV, Polyomavirus, SLL, Small lymphocytic lymphoma",

author = "Teman, \{Carolin J.\} and Tripp, \{Sheryl R.\} and Perkins, \{Sherrie L.\} and Duncavage, \{Eric J.\}",

year = "2011",

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doi = "10.1016/j.leukres.2011.01.032",

language = "English",

volume = "35",

pages = "689--692",

journal = "Leukemia Research",

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T1 - Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

AU - Teman, Carolin J.

AU - Tripp, Sheryl R.

AU - Perkins, Sherrie L.

AU - Duncavage, Eric J.

PY - 2011/5

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N2 - Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.

AB - Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.

KW - CLL

KW - Chronic lymphocytic leukemia

KW - MCPyV

KW - Polyomavirus

KW - SLL

KW - Small lymphocytic lymphoma

UR - https://www.scopus.com/pages/publications/79954613304

U2 - 10.1016/j.leukres.2011.01.032

DO - 10.1016/j.leukres.2011.01.032

M3 - Article

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AN - SCOPUS:79954613304

SN - 0145-2126

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SP - 689

EP - 692

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

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Keywords

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