Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

Carolin J. Teman, Sheryl R. Tripp, Sherrie L. Perkins, Eric J. Duncavage

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42 Scopus citations

Abstract

Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC. We tested for the presence of MCPyV by PCR and immunohistochemistry in 18 cases of CLL/SLL. Very low-level MCPyV DNA was detected in 33% of CLL/SLL cases by real-time PCR, but only one case demonstrated immunohistochemical positivity for MCPyV. MCPyV was not identified in 17 cases of follicular lymphoma, suggesting either that MCPyV is involved in CLL/SLL pathogenesis or that the immunodeficiency state of CLL/SLL induces low-level MCPyV reactivation.

Original languageEnglish
Pages (from-to)689-692
Number of pages4
JournalLeukemia Research
Volume35
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • CLL
  • Chronic lymphocytic leukemia
  • MCPyV
  • Polyomavirus
  • SLL
  • Small lymphocytic lymphoma

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