Menopausal hormone therapy and mortality among women diagnosed with ovarian cancer in the NIH-AARP Diet and Health Study

Ashley S. Felix, Kristen Bunch, Hannah P. Yang, Hannah Arem, Britton Trabert, Gretchen L. Gierach, Yikyung Park, William J. Lowery, Louise A. Brinton

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4 Scopus citations


Background Although menopausal hormone therapy (MHT) use has been linked with an increased risk of ovarian cancer, whether pre-diagnosis MHT use affects ovarian cancer-specific mortality is unknown. Methods Our analysis included 395 incident epithelial ovarian cancer patients with data on pre-diagnosis MHT use from the National Institutes of Health-AARP (NIH-AARP) Diet and Health Study. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for MHT type and ovarian cancer-specific mortality, adjusted for tumor characteristics, treatment, and other risk factors. Effect modification by histology (serous vs. non-serous) was examined using likelihood ratio tests comparing models with and without interaction terms between MHT type and histology. Results Ovarian cancer-specific mortality was not associated with pre-diagnosis estrogen-only therapy (ET) (HR = 1.09, 95% CI = 0.70-1.68) or estrogen plus progestin-only therapy (EPT) (HR = 0.97, 95% CI = 0.68-1.38). Neither recency of use nor specific regimen of EPT-only (sequential vs. continuous) was related to mortality. In analyses stratified by histology, no significant association between MHT type and ovarian cancer-specific mortality was observed among serous or non-serous cases; however, a significant interaction between MHT type and histology was noted (p-heterogeneity = 0.01). Conclusion Our results suggest that pre-diagnosis MHT use is not related to risk of ovarian cancer-specific death.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalGynecologic Oncology Reports
StatePublished - Aug 1 2015


  • Estrogen plus progestin
  • Menopausal hormone therapy
  • Mortality
  • Ovarian cancer


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