TY - JOUR
T1 - Meningeal Lymphatics in Central Nervous System Diseases
AU - Salvador, Andrea Francesca M.
AU - Abduljawad, Nora
AU - Kipnis, Jonathan
N1 - Publisher Copyright:
Copyright © 2024 by the author(s).
PY - 2024/8/8
Y1 - 2024/8/8
N2 - Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review, we discuss recent evidence of the contribution of meningeal lymphatics to neurological diseases, as well as the available experimental methods for manipulating meningeal lymphatics in these conditions. Finally, we also provide a discussion of the pressing questions and challenges in utilizing meningeal lymphatics as a prime target for CNS therapeutic intervention and possibly drug delivery for brain disorders.
AB - Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment, including brain tumors, inflammatory diseases such as multiple sclerosis, CNS injuries, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review, we discuss recent evidence of the contribution of meningeal lymphatics to neurological diseases, as well as the available experimental methods for manipulating meningeal lymphatics in these conditions. Finally, we also provide a discussion of the pressing questions and challenges in utilizing meningeal lymphatics as a prime target for CNS therapeutic intervention and possibly drug delivery for brain disorders.
KW - central nervous system
KW - drainage
KW - lymphatic vessels
KW - meninges
KW - neurodegeneration
KW - neuroimmunology
UR - http://www.scopus.com/inward/record.url?scp=85201029687&partnerID=8YFLogxK
U2 - 10.1146/annurev-neuro-113023-103045
DO - 10.1146/annurev-neuro-113023-103045
M3 - Review article
C2 - 38648267
AN - SCOPUS:85201029687
SN - 0147-006X
VL - 47
SP - 323
EP - 344
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
IS - 1
ER -