TY - JOUR
T1 - Memory-like natural killer cells for cancer immunotherapy
AU - Gang, Margery
AU - Wong, Pamela
AU - Berrien-Elliott, Melissa M.
AU - Fehniger, Todd A.
N1 - Funding Information:
Funding: This work was supported by the Howard Hughes Medical Institute (Medical Fellow Award). National Institutes of Health (NIH): T32HL00708843 , K12CA167540 , SPORE in Leukemia P50CA171963 , R01CA205239 . Additional funding from the Siteman Cancer Center P30CA091842 , V Foundation for Cancer Research, the Children's Discovery Institute (CDI) at WUSM, and the Jamie Erin Follicular Lymphoma Research Fund.
Funding Information:
Funding: This work was supported by the Howard Hughes Medical Institute (Medical Fellow Award). National Institutes of Health (NIH): T32HL00708843, K12CA167540, SPORE in Leukemia P50CA171963, R01CA205239. Additional funding from the Siteman Cancer Center P30CA091842, V Foundation for Cancer Research, the Children's Discovery Institute (CDI) at WUSM, and the Jamie Erin Follicular Lymphoma Research Fund.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/10
Y1 - 2020/10
N2 - Natural killer (NK) cells are cytotoxic innate lymphoid cells that protect the host from infection and mediate anti-tumor responses. Classically considered part of the innate immune system, NK cells were previously thought to not possess the specificity or enhanced recall responses associated with adaptive T and B lymphocytes. However, a large body of work has transformed these long-held divisions between innate and adaptive immunity; NK cell memory and memory-like responses are clearly established after hapten exposure, viral infection, and combined cytokine activation. These advances come with opportunities to translate innate NK cell recall responses into the clinic as cancer immunotherapy. Here, we review our current understanding of the heterogeneity of memory and memory-like NK cell responses, with distinct formation, molecular biology, and memory type functions. We elaborate on cytokine-induced memory-like NK cells and highlight their application as adoptive immunotherapy for cancer, and as a platform for engineering optimal NK cell anti-tumor responses.
AB - Natural killer (NK) cells are cytotoxic innate lymphoid cells that protect the host from infection and mediate anti-tumor responses. Classically considered part of the innate immune system, NK cells were previously thought to not possess the specificity or enhanced recall responses associated with adaptive T and B lymphocytes. However, a large body of work has transformed these long-held divisions between innate and adaptive immunity; NK cell memory and memory-like responses are clearly established after hapten exposure, viral infection, and combined cytokine activation. These advances come with opportunities to translate innate NK cell recall responses into the clinic as cancer immunotherapy. Here, we review our current understanding of the heterogeneity of memory and memory-like NK cell responses, with distinct formation, molecular biology, and memory type functions. We elaborate on cytokine-induced memory-like NK cells and highlight their application as adoptive immunotherapy for cancer, and as a platform for engineering optimal NK cell anti-tumor responses.
KW - Cancer immunotherapy
KW - Cytokine
KW - Cytokine receptor
KW - Cytokine-induced memory-like
KW - Innate memory
KW - Natural killer cell
UR - http://www.scopus.com/inward/record.url?scp=85097034902&partnerID=8YFLogxK
U2 - 10.1053/j.seminhematol.2020.11.003
DO - 10.1053/j.seminhematol.2020.11.003
M3 - Article
C2 - 33256911
AN - SCOPUS:85097034902
SN - 0037-1963
VL - 57
SP - 185
EP - 193
JO - Seminars in Hematology
JF - Seminars in Hematology
IS - 4
ER -