Memory improvement following induced hyperinsulinemia in Alzheimer's disease

Suzanne Craft, John Newcomer, Stephen Kanne, Samuel Dagogo-Jack, Philip Cryer, Yvette Sheline, Joan Luby, Agbani Dagogo-Jack, Amy Alderson

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Abstract

Dementia of the Alzheimer type (DAT) is accompanied by disruption in glucose regulation and utilization that may contribute to its characteristic memory impairment. Increasing glucose availability by raising plasma glucose improves memory in patients with DAT. Such memory improvement is associated with a secondary elevation in plasma insulin levels, raising the question of whether improvement is due to changes in insulin levels, independent of hyperglycemia. Distributions of insulin receptors in the hippocampus and insulin-mediated increases in glucose utilization in entorhinal cortex provide potential mechanisms for such improvement. We show that raising plasma insulin through intravenous infusion while keeping plasma glucose at a fasting baseline level produces striking memory enhancement for patients with DAT. Previous findings of hyperglycemic memory enhancement were also replicated. Patients with DAT also showed abnormal plasma levels of glucoregulatory hormones and metabolites at baseline and during metabolic manipulations. Our findings suggest that neuroendocrine factors play an important role in the pathophysiology of DAT.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalNeurobiology of Aging
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1996

Keywords

  • Alzheimer's disease
  • Hyperinsulinemia
  • Memory

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    Craft, S., Newcomer, J., Kanne, S., Dagogo-Jack, S., Cryer, P., Sheline, Y., Luby, J., Dagogo-Jack, A., & Alderson, A. (1996). Memory improvement following induced hyperinsulinemia in Alzheimer's disease. Neurobiology of Aging, 17(1), 123-130. https://doi.org/10.1016/0197-4580(95)02002-0