Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

H. Meziane, J. C. Dodart, C. Mathis, S. Little, J. Clemens, S. M. Paul, A. Ungerer

Research output: Contribution to journalArticlepeer-review

313 Scopus citations

Abstract

When administered intracerebroventricularly to mice performing various learning tasks involving either short-term or long-term memory, secreted forms of the β-amyloid precursor protein (APP(s)751 and APP(s)695) have potent memory-enhancing effects and block learning deficits induced by scopolamine. The memory-enhancing effects of APP(s) were observed over a wide range of extremely low doses (0.05-5,000 pg intracerebroventricularly), blocked by antiAPP(s) antisera, and observed when APP(s) was administered either after the first training session in a visual discrimination or a lever-press learning task or before the acquisition trial in an object recognition task. APP(s) had no effect on motor performance or exploratory activity. App(s)695 and Apps(s)751 were equally effective in the object recognition task, suggesting that the memory-enhancing effect of APP(s) does not require the Kunitz protease inhibitor domain. These data suggest an important role for APP(s)s on memory processes.

Original languageEnglish
Pages (from-to)12683-12688
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number21
DOIs
StatePublished - Oct 13 1998

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