Memory and insulin dependent diabetes mellitus (IDDM): Effects of childhood onset and severe hypoglycemia

Tamara Hershey, Suzanne Craft, Neil Bhargava, Neil H. White

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Previous studies of the neuropsychological consequences of insulin dependent diabetes mellitus (IDDM) have had mixed and often contradictory results, possibly due to the heterogeneity of the samples and neuropsychological measures, and a lack of specific hypotheses. In order to address this problem, we focused on the effect of severe hypoglycemia on memory functioning in a relatively homogeneous sample of childhood-onset IDDM patients. Given the deleterious effects of hypoglycemia on medial temporal lobe structures (e.g., hippocampus) and the relationship between medial temporal damage and declarative memory functioning, we hypothesized that those patients who had experienced severe hypoglycemia would demonstrate impaired declarative memory and spared nondeclarative memory functioning. Results of the study were generally consistent with this hypothesis, although some impact of hypoglycemia was observed on perceptual priming ability.

Original languageEnglish
Pages (from-to)509-520
Number of pages12
JournalJournal of the International Neuropsychological Society
Volume3
Issue number6
DOIs
StatePublished - Nov 1997

Keywords

  • Diabetes
  • Hypoglycemia
  • Memory

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