MEMBRANE TRANSPORT OF LONG CHAIN FATTY ACID IN THE ADIPOCYTE. AN IMPORTANT SITE FOR THE ACTION OF LIPOLYTIC AND ANTILIPOLYTIC HORMONES.

N. A. Abumrad, P. R. Perry, R. R. Whitesell

Research output: Contribution to journalConference article

Abstract

A membrane transport system for long chain fatty acids (FA) has been identified in the rat adipocyte. The process is freely reversible, does not require metabolic energy and has other characteristics of facilitated diffusion. FA transport can be stimulated up to 15 fold by catecholamines and ACTH. Insulin can completely suppress the stimulatory effect of catecholamine on FA transport but is without effect on the basal rate of uptake. Experiments suggest that accumulation of intracellular FA in the combined absence of glucose and the lipolytic inhibitor RHC80267 desensitizes the catecholamine-stimulated FA transport to insulin. In summary, the rate of FA transport at the level of the plasma membrane appears to play an important role in the control of FA mobilization by lipolytic and antilipolytic hormones.

Original languageEnglish
Number of pages1
JournalAnnals of biomedical engineering
Volume15
Issue number1
StatePublished - Jan 1 1987
Externally publishedYes
EventAbstr of Pap Presented at the Biomed Eng Soc Symp - Washington, DC, USA
Duration: Mar 29 1987Apr 3 1987

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