Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

Patrick R. O'Neill; Jean A. Castillo-Badillo; Xenia Meshik; Vani Kalyanaraman; Krystal Melgarejo; N. Gautam

doi:10.1016/j.devcel.2018.05.029

Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

Patrick R. O'Neill, Jean A. Castillo-Badillo, Xenia Meshik, Vani Kalyanaraman, Krystal Melgarejo, N. Gautam

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

O'Neill et al. use optogenetic control of two distinct migration modes to address the question of how propelling forces are generated during adhesion-independent cell migration. They show that rearward plasma membrane flow generates tangential viscous forces at the cell-liquid interface to drive the cell forward.

Original language	English
Pages (from-to)	9-22.e4
Journal	Developmental cell
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2018.05.029
State	Published - Jul 2 2018

Keywords

RhoA
cell adhesion
cell migration
endocytosis
membrane flow
optogenetics
signaling
viscous forces

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keywords = "RhoA, cell adhesion, cell migration, endocytosis, membrane flow, optogenetics, signaling, viscous forces",

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AU - Melgarejo, Krystal

AU - Gautam, N.

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KW - cell migration

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KW - membrane flow

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KW - signaling

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Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

Abstract

Keywords

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