Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

Patrick R. O'Neill, Jean A. Castillo-Badillo, Xenia Meshik, Vani Kalyanaraman, Krystal Melgarejo, N. Gautam

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


O'Neill et al. use optogenetic control of two distinct migration modes to address the question of how propelling forces are generated during adhesion-independent cell migration. They show that rearward plasma membrane flow generates tangential viscous forces at the cell-liquid interface to drive the cell forward.

Original languageEnglish
Pages (from-to)9-22.e4
JournalDevelopmental cell
Issue number1
StatePublished - Jul 2 2018


  • RhoA
  • cell adhesion
  • cell migration
  • endocytosis
  • membrane flow
  • optogenetics
  • signaling
  • viscous forces


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