TY - JOUR
T1 - Membrane cofactor protein (MCP; CD46)
T2 - deficiency states and pathogen connections
AU - Liszewski, Kathy
AU - Atkinson, John P.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/10
Y1 - 2021/10
N2 - Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome). CD46 also is a receptor for 11 pathogens (‘pathogen magnet’). While CD46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (COVID-19) vaccines. This review focuses on recent advances in identifying disease-causing CD46 variants and its pathogen connections.
AB - Membrane cofactor protein (MCP; CD46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor I to cleave and inactivate C3b and C4b deposited on host cells. However, CD46 also plays roles in human reproduction, autophagy, modulating T cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome). CD46 also is a receptor for 11 pathogens (‘pathogen magnet’). While CD46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (COVID-19) vaccines. This review focuses on recent advances in identifying disease-causing CD46 variants and its pathogen connections.
UR - http://www.scopus.com/inward/record.url?scp=85105776849&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2021.04.005
DO - 10.1016/j.coi.2021.04.005
M3 - Review article
C2 - 34004375
AN - SCOPUS:85105776849
SN - 0952-7915
VL - 72
SP - 126
EP - 134
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -