Membrane associated functions of neurokinin B (NKB) on Aβ (25-35) induced toxicity in aging rat brain synaptosomes

Anil K. Mantha, K. Moorthy, Sudha M. Cowsik, Najma Z. Baquer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The effect of different concentrations (0.1-5 μM) of neurokinin B (NKB) and Aβ (25-35) on acetylcholine esterase (AChE), Na+-K+ ATPase and membrane fluidity (DPH anisotropy) were investigated in rat brain synaptosomes of 3, 9, 18 and 30 months old. An age dependent decrease was observed for all the three parameters studied. An in vitro incubation of isolated brain synaptosomes with Aβ (25-35) showed toxic effects on all the parameters studied and the peptide had concentration and age dependent effects, while NKB showed stimulating effect on the parameters and the combined NKB+Aβ (25-35) incubations showed a partial reversal effect as compared to the Aβ (25-35) alone. Thus, the results suggest a membrane mediated function for NKB and its role in neuromodulation, neuroprotection and antioxidant property against Aβ (25-35) induced toxicity in aging brain functions.

Original languageEnglish
Pages (from-to)19-33
Number of pages15
JournalBiogerontology
Volume7
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Keywords

  • Aging
  • Amyloid beta protein
  • Membrane dynamics
  • Neurokinin B (NKB)
  • Neuroprotection
  • Oxidative stress and excitotoxicity
  • Tachykinins

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