Medullary carcinoma: Clinical practice guidelines in oncology™

R. Michael Turtle; Douglas W. Ball; David Byrd; Gilbert H. Daniels; Raza A. Dilawari; Gerard M. Doherty; Quan Yang Duh; Hormoz Ehya; William B. Farrar; Robert I. Haddad; Fouad Kandeel; Richard T. Kloos; Peter Kopp; Dominick M. Lamonica; Thom R. Loree; William M. Lydiatt; Judith McCaffrey; John A. Olson; Lee Parks; John A. Ridge; Jatin P. Shah; Steven I. Sherman; Steven G. Waguespack; Thomas N. Wang; Lori J. Wirth

doi:10.6004/jnccn.2010.0040

Medullary carcinoma: Clinical practice guidelines in oncology™

R. Michael Turtle, Douglas W. Ball, David Byrd, Gilbert H. Daniels, Raza A. Dilawari, Gerard M. Doherty, Quan Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith McCaffrey, John A. Olson, Lee Parks, John A. RidgeJatin P. Shah, Steven I. Sherman, Steven G. Waguespack, Thomas N. Wang, Lori J. Wirth

Research output: Contribution to journal › Review article › peer-review

72 Scopus citations

Abstract

These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.

Original language	English
Pages (from-to)	512-530
Number of pages	19
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	8
Issue number	5
DOIs	https://doi.org/10.6004/jnccn.2010.0040
State	Published - May 2010

Keywords

Cancer
External beam irradiation
Malignancy
Medullary thyroid cancer
NCCN clinical practice guidelines
Radiation therapy
Thyroid gland
Thyroidectomy
Tumor

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10.6004/jnccn.2010.0040

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Michael Turtle, R., Ball, D. W., Byrd, D., Daniels, G. H., Dilawari, R. A., Doherty, G. M., Duh, Q. Y., Ehya, H., Farrar, W. B., Haddad, R. I., Kandeel, F., Kloos, R. T., Kopp, P., Lamonica, D. M., Loree, T. R., Lydiatt, W. M., McCaffrey, J., Olson, J. A., Parks, L., ... Wirth, L. J. (2010). Medullary carcinoma: Clinical practice guidelines in oncology™. JNCCN Journal of the National Comprehensive Cancer Network, 8(5), 512-530. https://doi.org/10.6004/jnccn.2010.0040

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title = "Medullary carcinoma: Clinical practice guidelines in oncology{\texttrademark}",

abstract = "These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.",

keywords = "Cancer, External beam irradiation, Malignancy, Medullary thyroid cancer, NCCN clinical practice guidelines, Radiation therapy, Thyroid gland, Thyroidectomy, Tumor",

author = "{Michael Turtle}, R. and Ball, {Douglas W.} and David Byrd and Daniels, {Gilbert H.} and Dilawari, {Raza A.} and Doherty, {Gerard M.} and Duh, {Quan Yang} and Hormoz Ehya and Farrar, {William B.} and Haddad, {Robert I.} and Fouad Kandeel and Kloos, {Richard T.} and Peter Kopp and Lamonica, {Dominick M.} and Loree, {Thom R.} and Lydiatt, {William M.} and Judith McCaffrey and Olson, {John A.} and Lee Parks and Ridge, {John A.} and Shah, {Jatin P.} and Sherman, {Steven I.} and Waguespack, {Steven G.} and Wang, {Thomas N.} and Wirth, {Lori J.}",

year = "2010",

month = may,

doi = "10.6004/jnccn.2010.0040",

language = "English",

volume = "8",

pages = "512--530",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

issn = "1540-1405",

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Michael Turtle, R, Ball, DW, Byrd, D, Daniels, GH, Dilawari, RA, Doherty, GM, Duh, QY, Ehya, H, Farrar, WB, Haddad, RI, Kandeel, F, Kloos, RT, Kopp, P, Lamonica, DM, Loree, TR, Lydiatt, WM, McCaffrey, J, Olson, JA, Parks, L, Ridge, JA, Shah, JP, Sherman, SI, Waguespack, SG, Wang, TN & Wirth, LJ 2010, 'Medullary carcinoma: Clinical practice guidelines in oncology™', JNCCN Journal of the National Comprehensive Cancer Network, vol. 8, no. 5, pp. 512-530. https://doi.org/10.6004/jnccn.2010.0040

TY - JOUR

T1 - Medullary carcinoma

T2 - Clinical practice guidelines in oncology™

AU - Michael Turtle, R.

AU - Ball, Douglas W.

AU - Byrd, David

AU - Daniels, Gilbert H.

AU - Dilawari, Raza A.

AU - Doherty, Gerard M.

AU - Duh, Quan Yang

AU - Ehya, Hormoz

AU - Farrar, William B.

AU - Haddad, Robert I.

AU - Kandeel, Fouad

AU - Kloos, Richard T.

AU - Kopp, Peter

AU - Lamonica, Dominick M.

AU - Loree, Thom R.

AU - Lydiatt, William M.

AU - McCaffrey, Judith

AU - Olson, John A.

AU - Parks, Lee

AU - Ridge, John A.

AU - Shah, Jatin P.

AU - Sherman, Steven I.

AU - Waguespack, Steven G.

AU - Wang, Thomas N.

AU - Wirth, Lori J.

PY - 2010/5

Y1 - 2010/5

N2 - These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.

AB - These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.

KW - Cancer

KW - External beam irradiation

KW - Malignancy

KW - Medullary thyroid cancer

KW - NCCN clinical practice guidelines

KW - Radiation therapy

KW - Thyroid gland

KW - Thyroidectomy

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=77953007830&partnerID=8YFLogxK

U2 - 10.6004/jnccn.2010.0040

DO - 10.6004/jnccn.2010.0040

M3 - Review article

C2 - 20495082

AN - SCOPUS:77953007830

SN - 1540-1405

VL - 8

SP - 512

EP - 530

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 5

ER -

Medullary carcinoma: Clinical practice guidelines in oncology™

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Keywords

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