Medullary carcinoma: Clinical practice guidelines in oncology™

R. Michael Turtle, Douglas W. Ball, David Byrd, Gilbert H. Daniels, Raza A. Dilawari, Gerard M. Doherty, Quan Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith McCaffrey, John A. Olson, Lee Parks, John A. RidgeJatin P. Shah, Steven I. Sherman, Steven G. Waguespack, Thomas N. Wang, Lori J. Wirth

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on medullary thyroid carcinoma (MTC). NCCN Guidelines addressing papillarc follicular, HOrthle cell, and anaplastic thyroid carcinomas will appear in a later issue of JNCCN. Sporadic MTC accounts for approximately 80% of all cases of the disease. Sporadic disease typically presents in the fifth or sixth decade. Familial forms of the disease tend to present at earlier ages. Because the C cells are predominantly located in the upper portion of each thyroid lobe, patients with sporadic disease typically present with upper pole thyroid nodules. Metastatic cervical adenopathy appears in approximately 50% of patients at initial presentation. Symptoms of upper aerodigestive tract compression or invasion are reported by up to 15% of patients with sporadic disease. Symptoms from distant metastases in lungs or bones occur in 5% to 10% of patients. The risk for concomitant or subsequent development of pheochromocytoma and hyperparathyroidism must always be considered.

Original languageEnglish
Pages (from-to)512-530
Number of pages19
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number5
StatePublished - May 2010


  • Cancer
  • External beam irradiation
  • Malignancy
  • Medullary thyroid cancer
  • NCCN clinical practice guidelines
  • Radiation therapy
  • Thyroid gland
  • Thyroidectomy
  • Tumor


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