Medication use and mammographic breast density

Yunan Han, Chee Teik Lee, Shuai Xu, Xiaoyue Mi, Courtnie R. Phillip, Ana S. Salazar, Malika Rakhmankulova, Adetunji T. Toriola

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: A dense breast on mammogram is a strong risk factor for breast cancer. Identifying factors that reduce mammographic breast density could thus provide insight into breast cancer prevention. Due to the limited number of studies and conflicting findings, we investigated the associations of medication use (specifically statins, aspirin, and ibuprofen) with mammographic breast density. Methods: We evaluated these associations in 775 women who were recruited during an annual screening mammogram at Washington University School of Medicine, St. Louis. We measured mammographic breast density using Volpara. We used multivariable-adjusted linear regressions to determine the associations of medication use (statins, aspirin, and ibuprofen) with mammographic breast density. Least squared means were generated and back-transformed for easier interpretation. Results: The mean age of study participants was 52.9 years. Statin use in the prior 12 months was not associated with volumetric percent density or dense volume, but was positively associated with non-dense volume. The mean volumetric percent density was 8.6% among statin non-users, 7.2% among women who used statins 1–3 days/week, and 7.3% among women who used statins ≥ 4 days/week (p trend = 0.07). The non-dense volume was 1297.1 cm3 among statin non-users, 1368.7 cm3 among women who used statins 1–3 days/week, and 1408.4 cm3 among those who used statins ≥ 4 days/week (p trend = 0.02). We did not observe statistically significant differences in mammographic breast density by aspirin or ibuprofen use. Conclusion: Statin, aspirin, and ibuprofen use was not associated with volumetric percent density and dense volume, but statin use was positively associated with non-dense volume. Any potential associations of these medications with breast cancer risk are unlikely to be mediated through an effect on volumetric percent density.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalBreast Cancer Research and Treatment
Volume189
Issue number2
DOIs
StatePublished - Sep 2021

Keywords

  • Aspirin
  • Breast cancer
  • Ibuprofen
  • Mammographic breast density
  • NSAID
  • Statin

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