Mediators of oligodendrocyte differentiation during remyelination

Jigisha R. Patel, Robyn S. Klein

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

Myelin, a dielectric sheath that wraps large axons in the central and peripheral nervous systems, is essential for proper conductance of axon potentials. In multiple sclerosis (MS), autoimmune-mediated damage to myelin within the central nervous system (CNS) leads to progressive disability primarily due to limited endogenous repair of demyelination with associated axonal pathology. While treatments are available to limit demyelination, no treatments are available to promote myelin repair. Studies examining the molecular mechanisms that promote remyelination are therefore essential for identifying therapeutic targets to promote myelin repair and thereby limit disability in MS. Here, we present our current understanding of the critical extracellular and intracellular pathways that regulate the remyelinating capabilities of oligodendrocyte precursor cells (OPCs) within the adult CNS.

Original languageEnglish
Pages (from-to)3730-3737
Number of pages8
JournalFEBS Letters
Volume585
Issue number23
DOIs
StatePublished - Dec 1 2011

Keywords

  • Chemokines
  • Cytokines
  • Growth factor
  • MicroRNA
  • Multiple sclerosis
  • Transcription factor

Fingerprint

Dive into the research topics of 'Mediators of oligodendrocyte differentiation during remyelination'. Together they form a unique fingerprint.

Cite this