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MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes
Sabin A. Nettles
, Yoshiho Ikeuchi
, Katheryn B. Lefton
, Ladan Abbasi
, Alyssa Erickson
, Chibueze Agwu
,
Thomas Papouin
, Azad Bonni
,
Harrison W. Gabel
Department of Neuroscience
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Neurosciences
Institute of Clinical and Translational Sciences (ICTS)
Hope Center for Neurological Disorders
DBBS - Molecular Cell Biology
DBBS - Molecular Genetics and Genomics
Intellectual and Developmental Disabilities Research Center (IDDRC)
Research output
:
Contribution to journal
›
Article
›
peer-review
8
Scopus citations
Overview
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Keyphrases
Topoisomerase II
100%
Methyl-CpG-binding Protein 2 (MeCP2)
100%
Neuronal Genes
100%
Long Genes
62%
Regulated Genes
25%
Regulatory Region
12%
Overexpression
12%
Gene Expression
12%
Dysregulation
12%
High-level Expression
12%
Functional Interaction
12%
Neurological Disorders
12%
Neuronal Function
12%
Rett Syndrome
12%
Regulatory Genes
12%
Mouse Neuron
12%
Gene Body
12%
DNA Topoisomerase
12%
Unique Signatures
12%
Topological Constraints
12%
Topoisomerase II Inhibition
12%
Neuroscience
Methyl CpG Binding Protein 2
100%
DNA Gyrase
100%
Gene Expression
12%
Regulatory Region
12%
Nervous System Disorder
12%
Rett Syndrome
12%
Biochemistry, Genetics and Molecular Biology
Binding Protein
100%
DNA Gyrase
100%
Regulatory Region
12%
Gene Expression
12%
Regulatory Gene
12%
Rett Syndrome
12%