TY - JOUR
T1 - Mechanosensitive membrane proteins
T2 - Usual and unusual suspects in mediating mechanotransduction
AU - Goodman, Miriam B.
AU - Haswell, Elizabeth S.
AU - Vásquez, Valeria
N1 - Publisher Copyright:
© 2023 Goodman et al.
PY - 2023/3/6
Y1 - 2023/3/6
N2 - This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. Though researchers’ attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of the more unusual suspects, such as G-protein coupled receptors. As the field continues to grow, so too will the list of proteins suspected to function as mechanosensors and the diversity of known MS membrane proteins.
AB - This Viewpoint, which accompanies a Special Issue focusing on membrane mechanosensors, discusses unifying and unique features of both established and emerging mechanosensitive (MS) membrane proteins, their distribution across protein families and phyla, and current and future challenges in the study of these important proteins and their partners. MS membrane proteins are essential for tissue development, cellular motion, osmotic homeostasis, and sensing external and self-generated mechanical cues like those responsible for touch and proprioception. Though researchers’ attention and this Viewpoint focus on a few famous ion channels that are considered the usual suspects as MS mechanosensors, we also discuss some of the more unusual suspects, such as G-protein coupled receptors. As the field continues to grow, so too will the list of proteins suspected to function as mechanosensors and the diversity of known MS membrane proteins.
UR - http://www.scopus.com/inward/record.url?scp=85146892727&partnerID=8YFLogxK
U2 - 10.1085/jgp.202213248
DO - 10.1085/jgp.202213248
M3 - Article
C2 - 36696153
AN - SCOPUS:85146892727
SN - 0022-1295
VL - 155
JO - Journal of General Physiology
JF - Journal of General Physiology
IS - 3
M1 - e202213248
ER -